Gene description for HBEGF
Gene name heparin-binding EGF-like growth factor
Gene symbol HBEGF
Other names/aliases DTR
DTS
DTSF
HEGFL
Species Homo sapiens
 Database cross references - HBEGF
ExoCarta ExoCarta_1839
Vesiclepedia VP_1839
Entrez Gene 1839
HGNC 3059
MIM 126150
UniProt Q99075  
 HBEGF identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HBEGF
Molecular Function
    heparin binding GO:0008201 IMP
    epidermal growth factor receptor binding GO:0005154 IEA
    growth factor activity GO:0008083 IDA
Biological Process
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    negative regulation of elastin biosynthetic process GO:0051545 IEA
    positive regulation of wound healing GO:0090303 IMP
    positive regulation of cell growth GO:0030307 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of cell proliferation GO:0008284 IBA
    positive regulation of protein kinase B signaling GO:0051897 IMP
    muscle organ development GO:0007517 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    positive regulation of keratinocyte migration GO:0051549 IEA
    innate immune response GO:0045087 TAS
    regulation of heart contraction GO:0008016 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    positive regulation of cell migration GO:0030335 IMP
    wound healing, spreading of epidermal cells GO:0035313 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    signal transduction GO:0007165 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    extracellular region GO:0005576 TAS
    endocytic vesicle membrane GO:0030666 TAS
    extracellular space GO:0005615 TAS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    cell surface GO:0009986 NAS
 Experiment description of studies that identified HBEGF in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HBEGF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD44 960
Invivo Homo sapiens
2 BAG1 573
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 MMP7 4316
Affinity Capture-Western Homo sapiens
4 CD9 928
Invivo Homo sapiens
5 NRD1 4898
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
6 EGFR 1956
Affinity Capture-Western Homo sapiens
7 ZBTB16  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 CD82 3732
Affinity Capture-Western Homo sapiens
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