Gene description for CASP8
Gene name caspase 8, apoptosis-related cysteine peptidase
Gene symbol CASP8
Other names/aliases ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
Species Homo sapiens
 Database cross references - CASP8
ExoCarta ExoCarta_841
Vesiclepedia VP_841
Entrez Gene 841
HGNC 1509
MIM 601763
UniProt Q14790  
 CASP8 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CASP8
Molecular Function
    cysteine-type endopeptidase activity GO:0004197 IBA
    cysteine-type endopeptidase activity GO:0004197 IDA
    cysteine-type endopeptidase activity GO:0004197 IMP
    cysteine-type endopeptidase activity GO:0004197 TAS
    death receptor binding GO:0005123 IEA
    tumor necrosis factor receptor binding GO:0005164 IEA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 IDA
    peptidase activity GO:0008233 IMP
    cysteine-type peptidase activity GO:0008234 TAS
    ubiquitin protein ligase binding GO:0031625 IPI
    death effector domain binding GO:0035877 IPI
    identical protein binding GO:0042802 IPI
    protein-containing complex binding GO:0044877 IEA
    scaffold protein binding GO:0097110 IPI
Biological Process
    angiogenesis GO:0001525 ISS
    regulation of cytokine production GO:0001817 ISS
    proteolysis GO:0006508 IDA
    apoptotic process GO:0006915 IBA
    apoptotic process GO:0006915 IMP
    heart development GO:0007507 ISS
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IBA
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA
    regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 TAS
    natural killer cell activation GO:0030101 TAS
    macrophage differentiation GO:0030225 IBA
    macrophage differentiation GO:0030225 TAS
    positive regulation of cell migration GO:0030335 IDA
    response to cobalt ion GO:0032025 IEA
    response to estradiol GO:0032355 IEA
    response to lipopolysaccharide GO:0032496 IEA
    positive regulation of interleukin-1 beta production GO:0032731 IMP
    response to tumor necrosis factor GO:0034612 IMP
    TRAIL-activated apoptotic signaling pathway GO:0036462 IDA
    T cell activation GO:0042110 TAS
    B cell activation GO:0042113 TAS
    positive regulation of apoptotic process GO:0043065 ISS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP
    positive regulation of neuron apoptotic process GO:0043525 IBA
    regulation of innate immune response GO:0045088 ISS
    response to ethanol GO:0045471 IEA
    positive regulation of macrophage differentiation GO:0045651 IMP
    positive regulation of proteolysis GO:0045862 IDA
    proteolysis involved in protein catabolic process GO:0051603 IMP
    proteolysis involved in protein catabolic process GO:0051603 ISS
    protein maturation GO:0051604 IDA
    negative regulation of necroptotic process GO:0060546 IDA
    negative regulation of necroptotic process GO:0060546 ISS
    syncytiotrophoblast cell differentiation involved in labyrinthine layer development GO:0060715 TAS
    pyroptotic inflammatory response GO:0070269 ISS
    cellular response to mechanical stimulus GO:0071260 IEP
    cellular response to organic cyclic compound GO:0071407 IEA
    apoptotic signaling pathway GO:0097190 IMP
    apoptotic signaling pathway GO:0097190 TAS
    extrinsic apoptotic signaling pathway GO:0097191 IDA
    execution phase of apoptosis GO:0097194 IMP
    execution phase of apoptosis GO:0097194 ISS
    activation of cysteine-type endopeptidase activity GO:0097202 IDA
    self proteolysis GO:0097264 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 TAS
    mitochondrial outer membrane GO:0005741 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 TAS
    lamellipodium GO:0030027 IDA
    death-inducing signaling complex GO:0031264 IDA
    CD95 death-inducing signaling complex GO:0031265 IBA
    CD95 death-inducing signaling complex GO:0031265 IDA
    protein-containing complex GO:0032991 IDA
    cell body GO:0044297 IEA
    ripoptosome GO:0097342 IDA
 Experiment description of studies that identified CASP8 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CASP8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFAIP3 7128
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 NOD1 10392
Affinity Capture-Western Homo sapiens
3 CYLD  
Affinity Capture-Western Homo sapiens
4 CASP4  
Biochemical Activity Homo sapiens
5 GMNN  
Affinity Capture-MS Homo sapiens
6 XIAP  
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
7 TNFSF10 8743
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 BID  
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
9 RPA2 6118
Proximity Label-MS Homo sapiens
10 NLRC4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 TRADD 8717
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 Vangl1  
Affinity Capture-MS Mus musculus
13 VHL  
Negative Genetic Homo sapiens
14 RIPK1 8737
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 PARK7 11315
Reconstituted Complex Homo sapiens
16 ARHGDIA 396
Co-purification Homo sapiens
17 MAP1LC3B 81631
Two-hybrid Homo sapiens
18 NR1H4  
Reconstituted Complex Homo sapiens
19 FIS1 51024
Affinity Capture-Western Homo sapiens
20 TRIM28 10155
Affinity Capture-Western Homo sapiens
21 DYNC1LI2 1783
Proximity Label-MS Homo sapiens
22 APAF1 317
Affinity Capture-Western Homo sapiens
23 TLR3  
Affinity Capture-Western Homo sapiens
24 CASP3 836
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
25 COPS6 10980
Biochemical Activity Homo sapiens
26 SRC 6714
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 KHDRBS1 10657
Affinity Capture-Western Homo sapiens
28 RHOA 387
Co-purification Homo sapiens
29 NOL3 8996
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
30 PEA15 8682
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
31 DEDD  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 FAF1 11124
Affinity Capture-Western Homo sapiens
33 SNRPD3 6634
Two-hybrid Homo sapiens
34 USP27X  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 ATG4D  
Biochemical Activity Homo sapiens
36 BLM 641
Affinity Capture-MS Homo sapiens
37 USP2  
Affinity Capture-Western Homo sapiens
38 TFCP2 7024
Two-hybrid Homo sapiens
39 CHD3 1107
Two-hybrid Homo sapiens
40 CFLAR  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 BFAR  
Affinity Capture-Western Homo sapiens
42 RALGDS  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 SORBS1 10580
Affinity Capture-Western Homo sapiens
44 FAS 355
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
45 TNF  
Affinity Capture-Western Homo sapiens
46 MAPK1 5594
Affinity Capture-Western Homo sapiens
47 PLIN4  
Two-hybrid Homo sapiens
48 FASLG 356
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
49 TOPORS  
Affinity Capture-Western Homo sapiens
50 OPTN 10133
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 HDAC7  
Biochemical Activity Homo sapiens
52 MAPT  
Biochemical Activity Homo sapiens
53 OGT 8473
Reconstituted Complex Homo sapiens
54 CASP6 839
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
55 CHEK1  
Negative Genetic Homo sapiens
56 UBC 7316
Reconstituted Complex Homo sapiens
57 Sqstm1  
Biochemical Activity Mus musculus
58 BCL2L1 598
Phenotypic Suppression Homo sapiens
59 PML 5371
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
60 PDIA6 10130
Two-hybrid Homo sapiens
61 MAPK8 5599
Co-purification Homo sapiens
62 SKP2  
Affinity Capture-Western Homo sapiens
63 IFT57 55081
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 ANKRD13A 88455
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
65 RYBP  
Affinity Capture-Western Homo sapiens
66 TNFRSF10A 8797
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
68 BIRC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 BCAP31 10134
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
70 CASP14 23581
Affinity Capture-Western Homo sapiens
71 RNF34  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
72 BAX 581
Co-fractionation Homo sapiens
73 CUL3 8452
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 BIRC3 330
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
75 CRYAB 1410
Affinity Capture-Western Homo sapiens
76 TNFRSF1A 7132
Co-purification Homo sapiens
77 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
78 CASP2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
79 PTEN 5728
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
80 CARD11  
Affinity Capture-Western Homo sapiens
81 FADD 8772
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 PRKCI 5584
Two-hybrid Homo sapiens
83 BIRC6 57448
Biochemical Activity Homo sapiens
84 CASP9 842
Biochemical Activity Homo sapiens
Phenotypic Suppression Homo sapiens
Biochemical Activity Homo sapiens
85 DEDD2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
86 RPA3 6119
Proximity Label-MS Homo sapiens
87 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
88 MTOR 2475
Negative Genetic Homo sapiens
89 CASP10  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 HIP1 3092
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
91 MSN 4478
Co-purification Homo sapiens
92 CDKN1B 1027
Negative Genetic Homo sapiens
93 TSC22D3  
Affinity Capture-Western Homo sapiens
94 CHUK 1147
Affinity Capture-Western Homo sapiens
95 TICAM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
96 MLKL 197259
Affinity Capture-MS Homo sapiens
97 GSDMD 79792
Affinity Capture-Western Homo sapiens
98 RALBP1 10928
Affinity Capture-Western Homo sapiens
99 MAP3K14  
Affinity Capture-Western Homo sapiens
100 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
101 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
102 PARP1 142
Biochemical Activity Homo sapiens
103 CASP7  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
104 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
105 HECTD3 79654
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
106 EZR 7430
Co-purification Homo sapiens
107 IL1B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
108 RIPK3 11035
Affinity Capture-Western Homo sapiens
109 CASP8 841
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
110 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
111 ERLIN2 11160
Affinity Capture-MS Homo sapiens
112 GZMB  
Biochemical Activity Homo sapiens
113 TNFRSF10B 8795
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
114 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 BCL2  
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
116 LRRK2 120892
Affinity Capture-Western Homo sapiens
117 CASP1  
Biochemical Activity Homo sapiens
118 PRDX6 9588
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
119 CDK9 1025
Negative Genetic Homo sapiens
120 CEBPB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
121 CASP8AP2  
Affinity Capture-Western Homo sapiens
122 VIM 7431
Two-hybrid Homo sapiens
123 IKBKB 3551
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
124 CLIP3  
Affinity Capture-Western Homo sapiens
125 TRAF1 7185
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which CASP8 is involved
PathwayEvidenceSource
Activation, myristolyation of BID and translocation to mitochondria TAS Reactome
Apoptosis TAS Reactome
Apoptotic cleavage of cellular proteins TAS Reactome
Apoptotic execution phase TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
CASP8 activity is inhibited TAS Reactome
Caspase activation via Death Receptors in the presence of ligand TAS Reactome
Caspase activation via extrinsic apoptotic signalling pathway TAS Reactome
Caspase-mediated cleavage of cytoskeletal proteins TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
CLEC7A/inflammasome pathway TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Death Receptor Signaling TAS Reactome
Defective RIPK1-mediated regulated necrosis TAS Reactome
Dimerization of procaspase-8 TAS Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
FasL/ CD95L signaling TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Intrinsic Pathway for Apoptosis TAS Reactome
Microbial modulation of RIPK1-mediated regulated necrosis TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
Programmed Cell Death TAS Reactome
Regulated Necrosis TAS Reactome
Regulation by c-FLIP TAS Reactome
Regulation of necroptotic cell death TAS Reactome
Regulation of NF-kappa B signaling TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
RIPK1-mediated regulated necrosis TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TLR3-mediated TICAM1-dependent programmed cell death TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced proapoptotic signaling TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAIL signaling TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
TRIF-mediated programmed cell death TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here