Gene description for CASP6
Gene name caspase 6, apoptosis-related cysteine peptidase
Gene symbol CASP6
Other names/aliases MCH2
Species Homo sapiens
 Database cross references - CASP6
ExoCarta ExoCarta_839
Entrez Gene 839
HGNC 1507
MIM 601532
UniProt P55212  
 CASP6 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CASP6
Molecular Function
    cysteine-type endopeptidase activity GO:0004197 TAS
    cysteine-type peptidase activity GO:0008234 TAS
    protein binding GO:0005515 IPI
    cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 IBA
    identical protein binding GO:0042802 IPI
Biological Process
    proteolysis GO:0006508 IDA
    epithelial cell differentiation GO:0030855 IEP
    programmed cell death GO:0012501 TAS
    apoptotic process GO:0006915 TAS
    execution phase of apoptosis GO:0097194 IBA
    cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified CASP6 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CASP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPD1 3329
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 CHD3  
Two-hybrid Homo sapiens
3 CASP8  
Invivo Homo sapiens
Invitro Homo sapiens
4 LMNB1 4001
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
5 CASP10  
Invitro Homo sapiens
6 TRAF1 7185
Biochemical Activity Homo sapiens
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