Gene description for TNFSF10
Gene name	tumor necrosis factor (ligand) superfamily, member 10
Gene symbol	TNFSF10
Other names/aliases	APO2L Apo-2L CD253 TL2 TRAIL
Species	Homo sapiens
Database cross references - TNFSF10
ExoCarta	ExoCarta_8743
Entrez Gene	8743
HGNC	11925
MIM	603598
UniProt	P50591
TNFSF10 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	15940614
Saliva	19199708

Gene ontology annotations for TNFSF10

Molecular Function     tumor necrosis factor receptor binding GO:0005164 IEA     cytokine activity GO:0005125 IEA     receptor binding GO:0005102 TAS     metal ion binding GO:0046872 IEA     protein binding GO:0005515 IPI Biological Process     extrinsic apoptotic signaling pathway GO:0097191 TAS     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 TAS     apoptotic process GO:0006915 TAS     positive regulation of apoptotic process GO:0043065 IDA     necroptotic process GO:0070266 TAS     positive regulation of release of cytochrome c from mitochondria GO:0090200 IDA     programmed cell death GO:0012501 TAS     cell-cell signaling GO:0007267 TAS     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IDA     immune response GO:0006955 IEA     cell surface receptor signaling pathway GO:0007166 TAS     regulation of necrotic cell death GO:0010939 TAS     programmed necrotic cell death GO:0097300 TAS     response to insulin GO:0032868 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 TAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 TAS     positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IDA     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP     signal transduction GO:0007165 TAS     male gonad development GO:0008584 IEA Subcellular Localization     integral component of plasma membrane GO:0005887 TAS     extracellular space GO:0005615 IEA     extracellular exosome GO:0070062 IDA     extracellular region GO:0005576 TAS