Gene description for MOSPD2
Gene name motile sperm domain containing 2
Gene symbol MOSPD2
Other names/aliases -
Species Homo sapiens
 Database cross references - MOSPD2
ExoCarta ExoCarta_158747
Vesiclepedia VP_158747
Entrez Gene 158747
HGNC 28381
UniProt Q8NHP6  
 MOSPD2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MOSPD2
Molecular Function
    protein binding GO:0005515 IPI
    FFAT motif binding GO:0033149 IDA
Biological Process
    chemotaxis GO:0006935 IEA
    protein homooligomerization GO:0051260 IDA
    positive regulation of neutrophil chemotaxis GO:0090023 IDA
    positive regulation of monocyte chemotaxis GO:0090026 IDA
    lipid droplet formation GO:0140042 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    endomembrane system GO:0012505 IBA
    membrane GO:0016020 HDA
    specific granule membrane GO:0035579 TAS
    organelle membrane contact site GO:0044232 IDA
    endoplasmic reticulum-endosome membrane contact site GO:0140284 IBA
    endoplasmic reticulum-endosome membrane contact site GO:0140284 IDA
 Experiment description of studies that identified MOSPD2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MOSPD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STARD3NL 83930
Affinity Capture-MS Homo sapiens
2 REEP5 7905
Proximity Label-MS Homo sapiens
3 RRAS 6237
Affinity Capture-MS Homo sapiens
4 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SEC63 11231
Proximity Label-MS Homo sapiens
6 PALM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 CX3CL1  
Affinity Capture-MS Homo sapiens
9 DNAJC25 548645
Proximity Label-MS Homo sapiens
10 CXCR4 7852
Affinity Capture-MS Homo sapiens
11 RPN2 6185
Proximity Label-MS Homo sapiens
12 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 METTL7A 25840
Proximity Label-MS Homo sapiens
14 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 BTN1A1 696
Two-hybrid Homo sapiens
16 LAMP3  
Proximity Label-MS Homo sapiens
17 LRRC59 55379
Proximity Label-MS Homo sapiens
18 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 KIAA1715 80856
Proximity Label-MS Homo sapiens
21 PXMP2  
Proximity Label-MS Homo sapiens
22 GNG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NFATC1 4772
Affinity Capture-MS Homo sapiens
24 MARCH8  
Affinity Capture-MS Homo sapiens
25 CHRNA10  
Affinity Capture-MS Homo sapiens
26 FASLG 356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 BCAP31 10134
Proximity Label-MS Homo sapiens
28 PTPRN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GJD3  
Proximity Label-MS Homo sapiens
30 EMD 2010
Proximity Label-MS Homo sapiens
31 LAMP2 3920
Proximity Label-MS Homo sapiens
32 FKBP8 23770
Proximity Label-MS Homo sapiens
33 HSD3B7 80270
Proximity Label-MS Homo sapiens
34 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
36 DERL1 79139
Proximity Label-MS Homo sapiens
37 FAM187B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ELOVL5 60481
Proximity Label-MS Homo sapiens
39 SMIM5  
Affinity Capture-MS Homo sapiens
40 BTN2A3P  
Affinity Capture-MS Homo sapiens
41 GNG2 54331
Affinity Capture-MS Homo sapiens
42 PPP3R2  
Affinity Capture-MS Homo sapiens
43 CLEC12B  
Affinity Capture-MS Homo sapiens
44 PTPN5  
Affinity Capture-MS Homo sapiens
45 GNG12 55970
Affinity Capture-MS Homo sapiens
46 DCST1  
Affinity Capture-MS Homo sapiens
47 B3GAT1  
Proximity Label-MS Homo sapiens
48 LSMEM2  
Affinity Capture-MS Homo sapiens
49 SEC62 7095
Proximity Label-MS Homo sapiens
50 ATP2A1 487
Proximity Label-MS Homo sapiens
51 PTPN1 5770
Proximity Label-MS Homo sapiens
52 RAB7A 7879
Proximity Label-MS Homo sapiens
53 SRPR 6734
Affinity Capture-MS Homo sapiens
54 ACTB 60
Cross-Linking-MS (XL-MS) Homo sapiens
55 TGFA  
Affinity Capture-MS Homo sapiens
56 RPN1 6184
Proximity Label-MS Homo sapiens
57 DNAJC1 64215
Proximity Label-MS Homo sapiens
58 SSR1 6745
Proximity Label-MS Homo sapiens
59 SLC44A5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 OR13J1  
Affinity Capture-MS Homo sapiens
62 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 SEC61B 10952
Proximity Label-MS Homo sapiens
65 CCDC47 57003
Affinity Capture-MS Homo sapiens
66 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 RMDN3 55177
Proximity Label-MS Homo sapiens
68 SLC25A46 91137
Proximity Label-MS Homo sapiens
69 CLRN2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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