Gene description for ZFYVE27
Gene name zinc finger, FYVE domain containing 27
Gene symbol ZFYVE27
Other names/aliases PROTRUDIN
SPG33
Species Homo sapiens
 Database cross references - ZFYVE27
ExoCarta ExoCarta_118813
Vesiclepedia VP_118813
Entrez Gene 118813
HGNC 26559
MIM 610243
UniProt Q5T4F4  
 ZFYVE27 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ZFYVE27
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    vesicle-mediated transport GO:0016192 IBA
    vesicle-mediated transport GO:0016192 IDA
    neuron projection development GO:0031175 IBA
    neuron projection development GO:0031175 IDA
    positive regulation of axon extension GO:0045773 IBA
    positive regulation of axon extension GO:0045773 ISS
    neurotrophin TRK receptor signaling pathway GO:0048011 IBA
    neurotrophin TRK receptor signaling pathway GO:0048011 ISS
    endoplasmic reticulum tubular network formation GO:0071787 IBA
    endoplasmic reticulum tubular network formation GO:0071787 IMP
    protein localization to plasma membrane GO:0072659 IBA
    protein localization to plasma membrane GO:0072659 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 IDA
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    growth cone membrane GO:0032584 IBA
    growth cone membrane GO:0032584 ISS
    intracellular membrane-bounded organelle GO:0043231 IDA
    recycling endosome membrane GO:0055038 ISS
    endoplasmic reticulum tubular network GO:0071782 IBA
    endoplasmic reticulum tubular network GO:0071782 IDA
 Experiment description of studies that identified ZFYVE27 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZFYVE27
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 REEP5 7905
Proximity Label-MS Homo sapiens
3 SACM1L 22908
Two-hybrid Homo sapiens
4 TMEM14C 51522
Two-hybrid Homo sapiens
5 SLC30A8  
Two-hybrid Homo sapiens
6 SLC19A2 10560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ATPIF1 93974
Affinity Capture-MS Homo sapiens
8 SYNGR2 9144
Affinity Capture-MS Homo sapiens
9 RPN2 6185
Proximity Label-MS Homo sapiens
10 CUL3 8452
Affinity Capture-MS Homo sapiens
11 GPR17 2840
Affinity Capture-MS Homo sapiens
12 PQLC1  
Two-hybrid Homo sapiens
13 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 METTL7A 25840
Proximity Label-MS Homo sapiens
15 LRRC59 55379
Proximity Label-MS Homo sapiens
16 KIAA1715 80856
Proximity Label-MS Homo sapiens
17 APOB 338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 IER3IP1 51124
Two-hybrid Homo sapiens
19 ATP5A1 498
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 OTOP3  
Two-hybrid Homo sapiens
21 TMEM128  
Two-hybrid Homo sapiens
22 HSD3B7 80270
Proximity Label-MS Homo sapiens
23 TSPAN15 23555
Affinity Capture-MS Homo sapiens
24 ATP5F1 515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ATP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SDCCAG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 TNFSF18 8995
Affinity Capture-MS Homo sapiens
28 APP 351
Reconstituted Complex Homo sapiens
29 PSMD11 5717
Affinity Capture-MS Homo sapiens
30 ORMDL1 94101
Two-hybrid Homo sapiens
31 TSPAN2 10100
Two-hybrid Homo sapiens
32 GIMAP1  
Two-hybrid Homo sapiens
33 ACP2 53
Affinity Capture-MS Homo sapiens
34 DHX16 8449
Affinity Capture-MS Homo sapiens
35 RAB2A 5862
Affinity Capture-MS Homo sapiens
36 SEC62 7095
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GOLGA5 9950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ATP2A1 487
Proximity Label-MS Homo sapiens
39 TMEM243  
Two-hybrid Homo sapiens
40 SEC22A  
Two-hybrid Homo sapiens
41 ACACB 32
Affinity Capture-MS Homo sapiens
42 ATP5H 10476
Affinity Capture-MS Homo sapiens
43 SLC7A2 6542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 RAB7A 7879
Proximity Label-MS Homo sapiens
45 PLXDC2 84898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MOSPD2 158747
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ATP5C1 509
Affinity Capture-MS Homo sapiens
48 TMEM184B  
Affinity Capture-MS Homo sapiens
49 YES1 7525
Affinity Capture-MS Homo sapiens
50 TMEM55A 55529
Two-hybrid Homo sapiens
51 YIF1A 10897
Two-hybrid Homo sapiens
52 ZFAND2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 GIMAP5  
Two-hybrid Homo sapiens
54 ATP5B 506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 DERL1 79139
Proximity Label-MS Homo sapiens
56 TMEM65 157378
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZFYVE27 is involved
No pathways found





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