Gene description for ACACB
Gene name acetyl-CoA carboxylase beta
Gene symbol ACACB
Other names/aliases ACC2
ACCB
HACC275
Species Homo sapiens
 Database cross references - ACACB
ExoCarta ExoCarta_32
Entrez Gene 32
HGNC 85
MIM 601557
UniProt O00763  
 ACACB identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ACACB
Molecular Function
    ATP binding GO:0005524 IEA
    biotin binding GO:0009374 IEA
    acetyl-CoA carboxylase activity GO:0003989 IDA
    protein binding GO:0005515 IPI
    biotin carboxylase activity GO:0004075 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    energy reserve metabolic process GO:0006112 TAS
    response to organic cyclic compound GO:0014070 IEA
    biotin metabolic process GO:0006768 TAS
    carnitine shuttle GO:0006853 TAS
    positive regulation of cellular metabolic process GO:0031325 TAS
    protein homotetramerization GO:0051289 IDA
    fatty acid biosynthetic process GO:0006633 IEA
    positive regulation of heart growth GO:0060421 IEA
    negative regulation of fatty acid oxidation GO:0046322 IEA
    malonyl-CoA biosynthetic process GO:2001295 IEA
    response to drug GO:0042493 IEA
    cellular lipid metabolic process GO:0044255 TAS
    acetyl-CoA metabolic process GO:0006084 IDA
    vitamin metabolic process GO:0006766 TAS
    positive regulation of lipid storage GO:0010884 IEA
    water-soluble vitamin metabolic process GO:0006767 TAS
Subcellular Localization
    mitochondrial outer membrane GO:0005741 TAS
    mitochondrion GO:0005739 IDA
    endomembrane system GO:0012505 IEA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified ACACB in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACACB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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