Gene description for TSSK4
Gene name testis-specific serine kinase 4
Gene symbol TSSK4
Other names/aliases C14orf20
STK22E
TSK-4
TSK4
TSSK5
Species Homo sapiens
 Database cross references - TSSK4
ExoCarta ExoCarta_283629
Entrez Gene 283629
HGNC 19825
MIM 610711
UniProt Q6SA08  
 TSSK4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TSSK4
Molecular Function
    ATP binding GO:0005524 ISS
    magnesium ion binding GO:0000287 ISS
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activity GO:0004674 ISS
Biological Process
    multicellular organismal development GO:0007275 IEA
    positive regulation of CREB transcription factor activity GO:0032793 IDA
    protein phosphorylation GO:0006468 ISS
    spermatogenesis GO:0007283 IEA
    regulation of signal transduction GO:0009966 IEA
    cell differentiation GO:0030154 IEA
    intracellular signal transduction GO:0035556 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified TSSK4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TSSK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TSSK4 is involved
No pathways found





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