Gene description for STK16
Gene name serine/threonine kinase 16
Gene symbol STK16
Other names/aliases KRCT
MPSK
PKL12
TSF1
Species Homo sapiens
 Database cross references - STK16
ExoCarta ExoCarta_8576
Vesiclepedia VP_8576
Entrez Gene 8576
HGNC 11394
MIM 604719
UniProt O75716  
 STK16 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for STK16
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    protein serine/threonine kinase activity GO:0004674 IBA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    protein autophosphorylation GO:0046777 IDA
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi-associated vesicle GO:0005798 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified STK16 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for STK16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BHLHA9  
Two-hybrid Homo sapiens
2 CMTM6 54918
Affinity Capture-MS Homo sapiens
3 ZMAT1  
Two-hybrid Homo sapiens
4 KRTAP11-1  
Two-hybrid Homo sapiens
5 HEATR6  
Affinity Capture-MS Homo sapiens
6 OCLN 100506658
Affinity Capture-MS Homo sapiens
7 FRS3 10817
Two-hybrid Homo sapiens
8 RIN3  
Affinity Capture-MS Homo sapiens
9 AES 166
Two-hybrid Homo sapiens
10 REL 5966
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 FASTKD5  
Affinity Capture-MS Homo sapiens
12 MGAT5B  
Two-hybrid Homo sapiens
13 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MIIP 60672
Two-hybrid Homo sapiens
15 ROCK2 9475
Affinity Capture-MS Homo sapiens
16 VHL  
Affinity Capture-MS Homo sapiens
17 INTS1 26173
Affinity Capture-MS Homo sapiens
18 KRTAP13-2  
Two-hybrid Homo sapiens
19 SSC4D  
Two-hybrid Homo sapiens
20 SBSN 374897
Affinity Capture-MS Homo sapiens
21 SOCS2  
Two-hybrid Homo sapiens
22 Nedd4 25489
Biochemical Activity Rattus norvegicus
23 TCF12  
Two-hybrid Homo sapiens
24 DDIT4L  
Two-hybrid Homo sapiens
25 CALCOCO2  
Two-hybrid Homo sapiens
26 MTUS2 23281
Two-hybrid Homo sapiens
27 FLG 2312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 KPRP 448834
Two-hybrid Homo sapiens
29 EDAR  
Affinity Capture-MS Homo sapiens
30 TUBB 203068
Affinity Capture-MS Homo sapiens
31 NAGK 55577
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 DOCK1 1793
Affinity Capture-MS Homo sapiens
33 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
34 ARNT2  
Two-hybrid Homo sapiens
35 CSNK2B 1460
Two-hybrid Homo sapiens
36 PISD  
Affinity Capture-MS Homo sapiens
37 PTH1R  
Two-hybrid Homo sapiens
38 NIF3L1 60491
Two-hybrid Homo sapiens
39 RSPO4  
Two-hybrid Homo sapiens
40 KIAA0196 9897
Affinity Capture-MS Homo sapiens
41 ATP1A3 478
Affinity Capture-MS Homo sapiens
42 FAM154A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 ADAMTSL4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 POF1B 79983
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CNNM4 26504
Affinity Capture-MS Homo sapiens
46 PLSCR1 5359
Two-hybrid Homo sapiens
47 IRAK1  
Affinity Capture-MS Homo sapiens
48 ZNF330  
Two-hybrid Homo sapiens
49 GGT7 2686
Affinity Capture-MS Homo sapiens
50 DRG1 4733
Two-hybrid Homo sapiens
51 PCSK5 5125
Two-hybrid Homo sapiens
52 CCDC33 80125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 TRIM42  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 TUBA1A 7846
Affinity Capture-MS Homo sapiens
55 KRTAP13-1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 CFP  
Two-hybrid Homo sapiens
57 CBX3 11335
Two-hybrid Homo sapiens
58 C5orf30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TUBA1C 84790
Affinity Capture-MS Homo sapiens
60 SPRY4 81848
Affinity Capture-MS Homo sapiens
61 CYSRT1 375791
Two-hybrid Homo sapiens
62 MEOX2  
Two-hybrid Homo sapiens
63 AGR2 10551
Two-hybrid Homo sapiens
64 PRKAR1B  
Two-hybrid Homo sapiens
65 AHCTF1 25909
Affinity Capture-MS Homo sapiens
66 PKNOX2  
Two-hybrid Homo sapiens
67 KRTAP10-7  
Two-hybrid Homo sapiens
68 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
69 NOTCH2NL 388677
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
70 SEC63 11231
Affinity Capture-MS Homo sapiens
71 MIER3 166968
Two-hybrid Homo sapiens
72 RNF213 57674
Affinity Capture-MS Homo sapiens
73 MKKS  
Affinity Capture-MS Homo sapiens
74 KRTAP1-3  
Two-hybrid Homo sapiens
75 NAT6  
Two-hybrid Homo sapiens
76 IKZF3  
Two-hybrid Homo sapiens
77 KRTAP10-8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 CDC42EP1 11135
Affinity Capture-MS Homo sapiens
79 ICA1  
Affinity Capture-MS Homo sapiens
80 USP54 159195
Two-hybrid Homo sapiens
81 XRCC6BP1  
Two-hybrid Homo sapiens
82 GBF1 8729
Affinity Capture-MS Homo sapiens
83 KRTAP10-3  
Two-hybrid Homo sapiens
84 CRX  
Two-hybrid Homo sapiens
85 HNF4A  
Affinity Capture-MS Homo sapiens
86 DCAF10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 EBLN2  
Affinity Capture-MS Homo sapiens
88 UHRF1BP1 54887
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 RFX6  
Two-hybrid Homo sapiens
90 TRIM27  
Two-hybrid Homo sapiens
91 MROH1 727957
Affinity Capture-MS Homo sapiens
92 RPIA 22934
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
93 SPRY2 10253
Two-hybrid Homo sapiens
94 PASK  
Affinity Capture-MS Homo sapiens
95 KRTAP6-3  
Two-hybrid Homo sapiens
96 KRTAP10-5  
Two-hybrid Homo sapiens
97 TRIP6 7205
Two-hybrid Homo sapiens
98 TRAF3IP2  
Two-hybrid Homo sapiens
99 STK16 8576
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
100 EFHC2  
Two-hybrid Homo sapiens
101 SKIL  
Two-hybrid Homo sapiens
102 ALDH4A1 8659
Affinity Capture-MS Homo sapiens
103 FASTKD1  
Affinity Capture-MS Homo sapiens
104 TNFAIP1 7126
Two-hybrid Homo sapiens
105 FXR1 8087
Two-hybrid Homo sapiens
106 KCTD14 65987
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 INCA1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
108 NBPF19  
Two-hybrid Homo sapiens
109 DOPEY2 9980
Affinity Capture-MS Homo sapiens
110 ZNF774  
Two-hybrid Homo sapiens
111 DNAJA3 9093
Two-hybrid Homo sapiens
112 TUBB3 10381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 ELK1  
Biochemical Activity Homo sapiens
114 INTS2  
Affinity Capture-MS Homo sapiens
115 KRTAP1-1  
Two-hybrid Homo sapiens
116 EDC3 80153
Affinity Capture-MS Homo sapiens
117 SNRK  
Affinity Capture-MS Homo sapiens
118 PLSCR3 57048
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
119 METTL12  
Two-hybrid Homo sapiens
120 UBE3C 9690
Affinity Capture-MS Homo sapiens
121 TGIF1  
Affinity Capture-MS Homo sapiens
122 LPCAT2 54947
Affinity Capture-MS Homo sapiens
123 TCF4  
Two-hybrid Homo sapiens
124 KRTAP26-1  
Two-hybrid Homo sapiens
125 EXT2 2132
Affinity Capture-MS Homo sapiens
126 ATG4B 23192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 NCCRP1 342897
Affinity Capture-MS Homo sapiens
128 CNTF  
Affinity Capture-MS Homo sapiens
129 KCTD17 79734
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
130 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
131 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
132 GABPA 2551
Two-hybrid Homo sapiens
133 ALS2CR12  
Two-hybrid Homo sapiens
134 UNC119B 84747
Affinity Capture-MS Homo sapiens
135 EFEMP2 30008
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
136 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which STK16 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here