Gene description for UBE3C
Gene name ubiquitin protein ligase E3C
Gene symbol UBE3C
Other names/aliases HECTH2
Species Homo sapiens
 Database cross references - UBE3C
ExoCarta ExoCarta_9690
Entrez Gene 9690
HGNC 16803
MIM 614454
UniProt Q15386  
 UBE3C identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for UBE3C
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    ligase activity GO:0016874 IEA
Biological Process
    protein polyubiquitination GO:0000209 IDA
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    intracellular GO:0005622 IC
    proteasome complex GO:0000502 IEA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified UBE3C in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBE3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAND2 23066
Biochemical Activity Homo sapiens
2 PSMC5 5705
Affinity Capture-Western Homo sapiens
3 PSMD2 5708
Reconstituted Complex Homo sapiens
4 PSMD6 9861
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which UBE3C is involved
PathwayEvidenceSource
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome





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