Gene description for PIK3C3
Gene name phosphatidylinositol 3-kinase, catalytic subunit type 3
Gene symbol PIK3C3
Other names/aliases VPS34
Vps34
hVps34
Species Homo sapiens
 Database cross references - PIK3C3
ExoCarta ExoCarta_5289
Entrez Gene 5289
HGNC 8974
MIM 602609
UniProt Q8NEB9  
 PIK3C3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PIK3C3
Molecular Function
    protein kinase activity GO:0004672 IEA
    1-phosphatidylinositol-3-kinase activity GO:0016303 IMP
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    insulin receptor signaling pathway GO:0008286 TAS
    innate immune response GO:0045087 TAS
    peroxisome degradation GO:0030242 IBA
    macroautophagy GO:0016236 ISS
    toll-like receptor signaling pathway GO:0002224 TAS
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 TAS
    endosome organization GO:0007032 IEA
    early endosome to late endosome transport GO:0045022 IMP
    autophagosome assembly GO:0000045 IBA
    cellular response to glucose starvation GO:0042149 ISS
    toll-like receptor 9 signaling pathway GO:0034162 TAS
    response to leucine GO:0043201 IEA
    regulation of cytokinesis GO:0032465 IMP
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    phosphatidylinositol-mediated signaling GO:0048015 IBA
    endocytosis GO:0006897 IBA
    cytokinesis GO:0000910 IMP
    protein processing GO:0016485 IEA
    small molecule metabolic process GO:0044281 TAS
    phosphatidylinositol phosphorylation GO:0046854 IBA
    protein phosphorylation GO:0006468 IBA
    regulation of protein secretion GO:0050708 IEA
Subcellular Localization
    late endosome GO:0005770 IDA
    phosphatidylinositol 3-kinase complex, class III, type I GO:0034271 IBA
    phosphatidylinositol 3-kinase complex, class III GO:0035032 ISS
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IBA
    peroxisome GO:0005777 IBA
    axoneme GO:0005930 ISS
    midbody GO:0030496 IDA
    cytosol GO:0005829 TAS
    phosphatidylinositol 3-kinase complex, class III, type II GO:0034272 IBA
    phagocytic vesicle GO:0045335 IEA
    pre-autophagosomal structure GO:0000407 IBA
 Experiment description of studies that identified PIK3C3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PIK3C3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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