Gene description for JADE2
Gene name jade family PHD finger 2
Gene symbol JADE2
Other names/aliases JADE-2
PHF15
Species Homo sapiens
 Database cross references - JADE2
ExoCarta ExoCarta_23338
Entrez Gene 23338
HGNC 22984
MIM 610515
UniProt Q9NQC1  
 JADE2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for JADE2
Molecular Function
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
Biological Process
    histone H4-K16 acetylation GO:0043984 IDA
    histone H4-K5 acetylation GO:0043981 IDA
    histone H4-K12 acetylation GO:0043983 IDA
    SMAD protein signal transduction GO:0060395 IEA
    histone H4-K8 acetylation GO:0043982 IDA
    histone H3 acetylation GO:0043966 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    nucleoplasm GO:0005654 IDA
    histone acetyltransferase complex GO:0000123 IDA
 Experiment description of studies that identified JADE2 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for JADE2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which JADE2 is involved
PathwayEvidenceSource
HATs acetylate histones TAS Reactome





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