Gene description for PARD6G
Gene name par-6 family cell polarity regulator gamma
Gene symbol PARD6G
Other names/aliases PAR-6G
PAR6gamma
Species Homo sapiens
 Database cross references - PARD6G
ExoCarta ExoCarta_84552
Vesiclepedia VP_84552
Entrez Gene 84552
HGNC 16076
MIM 608976
UniProt Q9BYG4  
 PARD6G identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for PARD6G
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell junction assembly GO:0034329 TAS
    bicellular tight junction assembly GO:0070830 TAS
    cell cycle GO:0007049 IEA
    cell-cell junction organization GO:0045216 TAS
    cell division GO:0051301 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    bicellular tight junction GO:0005923 IEA
    protein complex GO:0043234 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified PARD6G in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PARD6G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKCZ 5590
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 PARD3 56288
Invivo Homo sapiens
Invitro Homo sapiens
3 CDC42 998
Invitro Homo sapiens
4 RAC1 5879
Invitro Homo sapiens
5 PRKCI 5584
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PARD6G is involved
PathwayEvidenceSource
Tight junction interactions TAS Reactome





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