Gene description for PARD6G
Gene name par-6 family cell polarity regulator gamma
Gene symbol PARD6G
Other names/aliases PAR-6G
PAR6gamma
Species Homo sapiens
 Database cross references - PARD6G
ExoCarta ExoCarta_84552
Vesiclepedia VP_84552
Entrez Gene 84552
HGNC 16076
MIM 608976
UniProt Q9BYG4  
 PARD6G identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for PARD6G
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    centrosome cycle GO:0007098 IBA
    establishment or maintenance of cell polarity GO:0007163 IBA
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 ISS
    cell division GO:0051301 IEA
    regulation of cellular localization GO:0060341 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    bicellular tight junction GO:0005923 IEA
    cell cortex GO:0005938 IBA
    apical plasma membrane GO:0016324 IBA
    tight junction GO:0070160 NAS
    PAR polarity complex GO:0120157 ISS
 Experiment description of studies that identified PARD6G in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PARD6G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 LLGL2 3993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RBM14 10432
Two-hybrid Homo sapiens
4 YWHAZ 7534
Affinity Capture-MS Homo sapiens
5 LLGL1 3996
Affinity Capture-MS Homo sapiens
6 CASK 8573
Two-hybrid Homo sapiens
7 YWHAE 7531
Affinity Capture-MS Homo sapiens
8 AKAP9 10142
Two-hybrid Homo sapiens
9 DMRTB1  
Two-hybrid Homo sapiens
10 PRKCZ 5590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
11 NR3C1 2908
Proximity Label-MS Homo sapiens
12 PNMAL1  
Affinity Capture-MS Homo sapiens
13 PNMA2  
Affinity Capture-MS Homo sapiens
14 KIFAP3 22920
Two-hybrid Homo sapiens
15 KBTBD7  
Affinity Capture-MS Homo sapiens
16 MCAM 4162
Proximity Label-MS Homo sapiens
17 CDC42 998
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
18 PRKCI 5584
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
19 RNF146  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
20 MARK2 2011
Affinity Capture-MS Homo sapiens
21 PNMA3  
Affinity Capture-MS Homo sapiens
22 PARD3 56288
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 WDR83  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
24 NDEL1 81565
Two-hybrid Homo sapiens
25 HSPA4 3308
Affinity Capture-MS Homo sapiens
26 EPHA2 1969
Proximity Label-MS Homo sapiens
27 RAC1 5879
Reconstituted Complex Homo sapiens
28 BRINP1  
Affinity Capture-MS Homo sapiens
29 PARD6B 84612
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RHOJ 57381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here