Gene description for GABARAP
Gene name GABA(A) receptor-associated protein
Gene symbol GABARAP
Other names/aliases ATG8A
GABARAP-a
MM46
Species Homo sapiens
 Database cross references - GABARAP
ExoCarta ExoCarta_11337
Vesiclepedia VP_11337
Entrez Gene 11337
HGNC 4067
MIM 605125
UniProt O95166  
 GABARAP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GABARAP
Molecular Function
    GABA receptor binding GO:0050811 IPI
    microtubule binding GO:0008017 IBA
    beta-tubulin binding GO:0048487 IDA
    protein binding GO:0005515 IPI
Biological Process
    protein targeting GO:0006605 TAS
    nucleophagy GO:0044804 IBA
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA
    autophagosome assembly GO:0000045 IBA
    mitochondrion degradation GO:0000422 IBA
    synaptic transmission GO:0007268 TAS
    microtubule cytoskeleton organization GO:0000226 IEA
    membrane fusion GO:0061025 IBA
Subcellular Localization
    cell body GO:0044297 IEA
    cytosol GO:0005829 IBA
    lysosome GO:0005764 IEA
    pre-autophagosomal structure GO:0000407 IBA
    smooth endoplasmic reticulum GO:0005790 IEA
    plasma membrane GO:0005886 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    microtubule associated complex GO:0005875 IEA
    autophagosome GO:0005776 IDA
    actin cytoskeleton GO:0015629 IEA
    axoneme GO:0005930 ISS
    extrinsic component of membrane GO:0019898 IBA
    cytoplasmic vesicle GO:0031410 IEA
    microtubule GO:0005874 IEA
    Golgi membrane GO:0000139 IEA
    autophagosome membrane GO:0000421 IDA
 Experiment description of studies that identified GABARAP in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GABARAP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ULK1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 GABRG2  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 TUBB3 10381
Two-hybrid Homo sapiens
4 TFRC 7037
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 GABARAP 11337
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
6 NSF 4905
Invitro Homo sapiens
Invivo Homo sapiens
7 ATG4B 23192
Two-hybrid Homo sapiens
8 ATG3 64422
Invivo Homo sapiens
9 HDAC5 10014
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GABARAP is involved
No pathways found





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