Gene description for ATG3
Gene name autophagy related 3
Gene symbol ATG3
Other names/aliases APG3
APG3-LIKE
APG3L
PC3-96
Species Homo sapiens
 Database cross references - ATG3
ExoCarta ExoCarta_64422
Entrez Gene 64422
HGNC 20962
MIM 609606
UniProt Q9NT62  
 ATG3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ATG3
Molecular Function
    Atg12 transferase activity GO:0019777 ISS
    ubiquitin-like protein transferase activity GO:0019787 IDA
    ligase activity GO:0016874 IEA
    Atg8 ligase activity GO:0019776 ISS
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
Biological Process
    nucleophagy GO:0044804 IBA
    regulation of cilium assembly GO:1902017 ISS
    mitochondrion degradation GO:0000422 IBA
    protein targeting to membrane GO:0006612 ISS
    protein ubiquitination GO:0016567 IDA
    cellular protein modification process GO:0006464 IDA
    mitochondrial fragmentation involved in apoptotic process GO:0043653 ISS
    autophagosome assembly GO:0000045 ISS
Subcellular Localization
    cytosol GO:0005829 IDA
    cytoplasmic ubiquitin ligase complex GO:0000153 IPI
 Experiment description of studies that identified ATG3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATG3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GABARAP  
Invivo Homo sapiens
2 GABARAPL2 11345
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATG3 is involved
No pathways found





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