Gene description for MRPL49
Gene name mitochondrial ribosomal protein L49
Gene symbol MRPL49
Other names/aliases C11orf4
L49mt
MRP-L49
NOF
NOF1
Species Homo sapiens
 Database cross references - MRPL49
ExoCarta ExoCarta_740
Vesiclepedia VP_740
Entrez Gene 740
HGNC 1176
MIM 606866
UniProt Q13405  
 MRPL49 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL49
Molecular Function
    structural constituent of ribosome GO:0003735 IBA
    protein binding GO:0005515 IPI
Biological Process
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial ribosome GO:0005761 IDA
    mitochondrial large ribosomal subunit GO:0005762 IBA
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL49 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL49
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 MIS12  
Affinity Capture-MS Homo sapiens
3 SLIRP 81892
Proximity Label-MS Homo sapiens
4 H1FNT  
Affinity Capture-MS Homo sapiens
5 MRPL30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MRPL17  
Affinity Capture-MS Homo sapiens
7 TRUB2  
Proximity Label-MS Homo sapiens
8 MTG2  
Proximity Label-MS Homo sapiens
9 NGRN  
Proximity Label-MS Homo sapiens
10 HRAS 3265
Affinity Capture-MS Homo sapiens
11 CHCHD1  
Proximity Label-MS Homo sapiens
12 MRPL37 51253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MRPL27 51264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NENF 29937
Co-fractionation Homo sapiens
15 CAND1 55832
Affinity Capture-MS Homo sapiens
16 MRPL52  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
17 RPUSD4 84881
Proximity Label-MS Homo sapiens
18 DNAJC15  
Proximity Label-MS Homo sapiens
19 MTRF1  
Proximity Label-MS Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
21 Ecd  
Affinity Capture-MS Mus musculus
22 LRPPRC 10128
Proximity Label-MS Homo sapiens
23 Spire2  
Affinity Capture-MS Mus musculus
24 MCU 90550
Proximity Label-MS Homo sapiens
25 PRKCDBP 112464
Co-fractionation Homo sapiens
26 PMPCA 23203
Proximity Label-MS Homo sapiens
27 MCM2 4171
Affinity Capture-MS Homo sapiens
28 MRPL23 6150
Affinity Capture-MS Homo sapiens
29 CDH2 1000
Co-fractionation Homo sapiens
30 COPS5 10987
Affinity Capture-MS Homo sapiens
31 TRA2B 6434
Affinity Capture-MS Homo sapiens
32 HINT2 84681
Proximity Label-MS Homo sapiens
33 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ZFYVE1 53349
Affinity Capture-MS Homo sapiens
35 RPS9 6203
Affinity Capture-MS Homo sapiens
36 MRPS26 64949
Proximity Label-MS Homo sapiens
37 SURF1  
Proximity Label-MS Homo sapiens
38 EXD2  
Proximity Label-MS Homo sapiens
39 MRPL39 54148
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CEP57  
Affinity Capture-MS Homo sapiens
41 NHP2 55651
Affinity Capture-MS Homo sapiens
42 METTL18  
Affinity Capture-MS Homo sapiens
43 CUL1 8454
Affinity Capture-MS Homo sapiens
44 BTRC 8945
Affinity Capture-MS Homo sapiens
45 PMPCB 9512
Proximity Label-MS Homo sapiens
46 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 FASTKD2  
Proximity Label-MS Homo sapiens
48 VWA8 23078
Proximity Label-MS Homo sapiens
49 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RPL19 6143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 MTERF3  
Proximity Label-MS Homo sapiens
52 MDH2 4191
Proximity Label-MS Homo sapiens
53 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 MRPL13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SCFD1 23256
Co-fractionation Homo sapiens
56 C6orf203  
Proximity Label-MS Homo sapiens
57 THEM4  
Affinity Capture-MS Homo sapiens
58 COX15 1355
Affinity Capture-MS Homo sapiens
59 FASTKD5  
Proximity Label-MS Homo sapiens
60 MRPL45 84311
Affinity Capture-MS Homo sapiens
61 RPL26 6154
Affinity Capture-MS Homo sapiens
62 TMEM177  
Co-fractionation Homo sapiens
63 SRSF3 6428
Affinity Capture-MS Homo sapiens
64 YBX2 51087
Affinity Capture-MS Homo sapiens
65 PPT2  
Co-fractionation Homo sapiens
66 TUFM 7284
Proximity Label-MS Homo sapiens
67 MTIF3  
Proximity Label-MS Homo sapiens
68 HSCB 150274
Proximity Label-MS Homo sapiens
69 RBMS2 5939
Affinity Capture-MS Homo sapiens
70 CCDC109B 55013
Proximity Label-MS Homo sapiens
71 MOV10 4343
Affinity Capture-RNA Homo sapiens
72 RPL27A 6157
Affinity Capture-MS Homo sapiens
73 MTFMT  
Proximity Label-MS Homo sapiens
74 MRPL11 65003
Proximity Label-MS Homo sapiens
75 MTRF1L  
Proximity Label-MS Homo sapiens
76 TMEM70  
Proximity Label-MS Homo sapiens
77 CYLD  
Affinity Capture-MS Homo sapiens
78 MRPL2 51069
Affinity Capture-MS Homo sapiens
79 MRPL41 64975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 Brwd3  
Affinity Capture-MS Mus musculus
81 OXA1L  
Reconstituted Complex Homo sapiens
82 MRPL44  
Affinity Capture-MS Homo sapiens
83 MRPL51 51258
Affinity Capture-MS Homo sapiens
84 MRPL21 219927
Affinity Capture-MS Homo sapiens
85 MRRF  
Proximity Label-MS Homo sapiens
86 MRPS12  
Proximity Label-MS Homo sapiens
87 MTIF2 4528
Proximity Label-MS Homo sapiens
88 MRPL35  
Affinity Capture-MS Homo sapiens
89 MRPL10 124995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 MRPL9 65005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 RPL37 6167
Affinity Capture-MS Homo sapiens
92 PRKCZ 5590
Affinity Capture-MS Homo sapiens
93 CUL3 8452
Affinity Capture-MS Homo sapiens
94 TCF3  
Affinity Capture-MS Homo sapiens
95 MECP2 4204
Affinity Capture-MS Homo sapiens
96 GADD45GIP1  
Affinity Capture-MS Homo sapiens
97 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 NXF1 10482
Affinity Capture-RNA Homo sapiens
99 MRPL15 29088
Affinity Capture-MS Homo sapiens
100 MRPL1  
Affinity Capture-MS Homo sapiens
101 MYCN  
Affinity Capture-MS Homo sapiens
102 TACO1  
Proximity Label-MS Homo sapiens
103 MTG1  
Proximity Label-MS Homo sapiens
104 MRPL38  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
105 MYC  
Affinity Capture-MS Homo sapiens
106 DLST 1743
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
107 ACAD9 28976
Proximity Label-MS Homo sapiens
108 NANOG  
Affinity Capture-MS Homo sapiens
109 METTL15  
Proximity Label-MS Homo sapiens
110 MRPL18 29074
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 Fbxw11  
Affinity Capture-MS Mus musculus
112 SOX2  
Affinity Capture-MS Homo sapiens
113 GFM2 84340
Proximity Label-MS Homo sapiens
114 YBX1 4904
Affinity Capture-MS Homo sapiens
115 CS 1431
Proximity Label-MS Homo sapiens
116 MRPL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
118 FBXW11  
Affinity Capture-MS Homo sapiens
119 TSFM 10102
Proximity Label-MS Homo sapiens
120 AUH 549
Proximity Label-MS Homo sapiens
121 KIAA1598 57698
Affinity Capture-MS Homo sapiens
122 TBRG4 9238
Proximity Label-MS Homo sapiens
123 DNAJC19 131118
Proximity Label-MS Homo sapiens
124 Osgep  
Affinity Capture-MS Mus musculus
125 RPL6 6128
Affinity Capture-MS Homo sapiens
126 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
127 MRPL53  
Affinity Capture-MS Homo sapiens
128 TIMM10  
Co-fractionation Homo sapiens
129 DNAJA3 9093
Proximity Label-MS Homo sapiens
130 C12orf65  
Proximity Label-MS Homo sapiens
131 MTHFD1 4522
Co-fractionation Homo sapiens
132 C21orf33  
Proximity Label-MS Homo sapiens
133 SSBP1 6742
Proximity Label-MS Homo sapiens
134 KLF12  
Affinity Capture-MS Homo sapiens
135 FASTKD3  
Proximity Label-MS Homo sapiens
136 GFM1 85476
Proximity Label-MS Homo sapiens
137 MGST3 4259
Co-fractionation Homo sapiens
138 MRPL46  
Affinity Capture-MS Homo sapiens
139 RPUSD3  
Proximity Label-MS Homo sapiens
140 MRPL19 9801
Affinity Capture-MS Homo sapiens
141 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 HNRNPA1L2 144983
Affinity Capture-MS Homo sapiens
143 GRSF1 2926
Proximity Label-MS Homo sapiens
144 C1QBP 708
Proximity Label-MS Homo sapiens
145 HNRNPU 3192
Affinity Capture-MS Homo sapiens
146 C17orf80 55028
Proximity Label-MS Homo sapiens
147 METTL17  
Proximity Label-MS Homo sapiens
148 MRPL28 10573
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 MRPS18A  
Affinity Capture-MS Homo sapiens
150 DDX28  
Proximity Label-MS Homo sapiens
151 RPL17 6139
Affinity Capture-MS Homo sapiens
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