Gene description for MRPL45
Gene name mitochondrial ribosomal protein L45
Gene symbol MRPL45
Other names/aliases L45mt
MRP-L45
Species Homo sapiens
 Database cross references - MRPL45
ExoCarta ExoCarta_84311
Entrez Gene 84311
HGNC 16651
MIM 611850
 MRPL45 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MRPL45
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    organelle organization GO:0006996 TAS
    mitochondrial translational initiation GO:0070124 TAS
    mitochondrial translational termination GO:0070126 TAS
    mitochondrial translational elongation GO:0070125 TAS
    mitochondrial translation GO:0032543 TAS
Subcellular Localization
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 TAS
    ribosome GO:0005840 IEA
 Experiment description of studies that identified MRPL45 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MRPL45
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MRPL45 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here