Gene description for MRPL45
Gene name mitochondrial ribosomal protein L45
Gene symbol MRPL45
Other names/aliases L45mt
MRP-L45
Species Homo sapiens
 Database cross references - MRPL45
ExoCarta ExoCarta_84311
Vesiclepedia VP_84311
Entrez Gene 84311
HGNC 16651
MIM 611850
 MRPL45 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MRPL45
Molecular Function
    RNA binding GO:0003723 HDA
    structural constituent of ribosome GO:0003735 IDA
    protein binding GO:0005515 IPI
Biological Process
    mitochondrial translation GO:0032543 IDA
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL45 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MRPL45
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLEKHA3  
Two-hybrid Homo sapiens
2 NUPL2 11097
Affinity Capture-MS Homo sapiens
3 SLIRP 81892
Proximity Label-MS Homo sapiens
4 H1FNT  
Affinity Capture-MS Homo sapiens
5 RBMS3  
Affinity Capture-MS Homo sapiens
6 MRPL30  
Affinity Capture-MS Homo sapiens
7 MRPL17  
Affinity Capture-MS Homo sapiens
8 ZNF324B  
Affinity Capture-MS Homo sapiens
9 RPL13A 23521
Affinity Capture-MS Homo sapiens
10 TRUB2  
Proximity Label-MS Homo sapiens
11 MTG2  
Proximity Label-MS Homo sapiens
12 NGRN  
Proximity Label-MS Homo sapiens
13 CHCHD1  
Proximity Label-MS Homo sapiens
14 MRPL10 124995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MRPL27 51264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ZC3H4 23211
Co-fractionation Homo sapiens
17 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
18 HNRNPR 10236
Co-fractionation Homo sapiens
19 RPUSD4 84881
Proximity Label-MS Homo sapiens
20 MRPL49 740
Affinity Capture-MS Homo sapiens
21 DNAJC15  
Proximity Label-MS Homo sapiens
22 MTRF1  
Proximity Label-MS Homo sapiens
23 GFM2 84340
Proximity Label-MS Homo sapiens
24 CCDC90B  
Proximity Label-MS Homo sapiens
25 LRPPRC 10128
Proximity Label-MS Homo sapiens
26 KIAA1429 25962
Affinity Capture-MS Homo sapiens
27 SNRNP70 6625
Affinity Capture-MS Homo sapiens
28 MCU 90550
Proximity Label-MS Homo sapiens
29 TFAM 7019
Proximity Label-MS Homo sapiens
30 PMPCA 23203
Proximity Label-MS Homo sapiens
31 SDHB 6390
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
32 MRPL23 6150
Affinity Capture-MS Homo sapiens
33 PRC1 9055
Affinity Capture-MS Homo sapiens
34 HINT2 84681
Proximity Label-MS Homo sapiens
35 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 DDX58 23586
Affinity Capture-RNA Homo sapiens
37 MRPS26 64949
Proximity Label-MS Homo sapiens
38 SURF1  
Proximity Label-MS Homo sapiens
39 EXD2  
Proximity Label-MS Homo sapiens
40 MARCKSL1 65108
Co-fractionation Homo sapiens
41 MRPL39 54148
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 NDUFV1 4723
Co-fractionation Homo sapiens
43 Dctn5  
Affinity Capture-MS Mus musculus
44 MECP2 4204
Affinity Capture-MS Homo sapiens
45 PMPCB 9512
Proximity Label-MS Homo sapiens
46 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 FASTKD2  
Proximity Label-MS Homo sapiens
48 VWA8 23078
Proximity Label-MS Homo sapiens
49 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
50 RPL19 6143
Affinity Capture-MS Homo sapiens
51 MTERF3  
Proximity Label-MS Homo sapiens
52 KIF14 9928
Affinity Capture-MS Homo sapiens
53 MDH2 4191
Proximity Label-MS Homo sapiens
54 TACO1  
Proximity Label-MS Homo sapiens
55 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MRPL13  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
57 Nup188  
Affinity Capture-MS Mus musculus
58 MRPL32 64983
Co-fractionation Homo sapiens
59 C6orf203  
Proximity Label-MS Homo sapiens
60 FASTKD5  
Proximity Label-MS Homo sapiens
61 EMD 2010
Two-hybrid Homo sapiens
62 RPL26 6154
Affinity Capture-MS Homo sapiens
63 TMEM177  
Co-fractionation Homo sapiens
64 MALSU1  
Affinity Capture-MS Homo sapiens
65 SRSF3 6428
Affinity Capture-MS Homo sapiens
66 YBX2 51087
Affinity Capture-MS Homo sapiens
67 TUFM 7284
Proximity Label-MS Homo sapiens
68 PURG  
Affinity Capture-MS Homo sapiens
69 MTIF3  
Proximity Label-MS Homo sapiens
70 HSCB 150274
Proximity Label-MS Homo sapiens
71 RPL35 11224
Affinity Capture-MS Homo sapiens
72 NCAPD3 23310
Affinity Capture-MS Homo sapiens
73 SYNJ2BP 55333
Co-fractionation Homo sapiens
74 RBMS2 5939
Affinity Capture-MS Homo sapiens
75 FGF8  
Affinity Capture-MS Homo sapiens
76 CCDC109B 55013
Proximity Label-MS Homo sapiens
77 ZNF131  
Affinity Capture-MS Homo sapiens
78 TBRG4 9238
Proximity Label-MS Homo sapiens
79 RPL27A 6157
Affinity Capture-MS Homo sapiens
80 CHMP4B 128866
Affinity Capture-MS Homo sapiens
81 SPDYE4  
Affinity Capture-MS Homo sapiens
82 MRPL11 65003
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
83 MTRF1L  
Proximity Label-MS Homo sapiens
84 TMEM70  
Proximity Label-MS Homo sapiens
85 FOXS1  
Affinity Capture-MS Homo sapiens
86 MRPL2 51069
Affinity Capture-MS Homo sapiens
87 TRIM23 373
Two-hybrid Homo sapiens
88 MRPL41 64975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 MRPL44  
Affinity Capture-MS Homo sapiens
90 MRPL51 51258
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
91 WBSCR16  
Co-fractionation Homo sapiens
92 MRPL21 219927
Affinity Capture-MS Homo sapiens
93 MRRF  
Proximity Label-MS Homo sapiens
94 ABT1 29777
Affinity Capture-MS Homo sapiens
95 MRPS12  
Proximity Label-MS Homo sapiens
96 AURKAIP1  
Affinity Capture-MS Homo sapiens
97 MTIF2 4528
Proximity Label-MS Homo sapiens
98 MRPL24  
Co-fractionation Homo sapiens
99 MRPL35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 ECT2 1894
Affinity Capture-MS Homo sapiens
101 CLPP 8192
Proximity Label-MS Homo sapiens
102 MRPL37 51253
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SRSF4 6429
Affinity Capture-MS Homo sapiens
104 MRPL9 65005
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
105 RPL37 6167
Affinity Capture-MS Homo sapiens
106 PRKCZ 5590
Affinity Capture-MS Homo sapiens
107 CUL3 8452
Affinity Capture-MS Homo sapiens
108 RPUSD3  
Proximity Label-MS Homo sapiens
109 EGFR 1956
Negative Genetic Homo sapiens
110 FAHD1 81889
Affinity Capture-MS Homo sapiens
111 GADD45GIP1  
Affinity Capture-MS Homo sapiens
112 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
113 FOXL1  
Affinity Capture-MS Homo sapiens
114 KBTBD7  
Affinity Capture-MS Homo sapiens
115 MRPL15 29088
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
116 MRPL1  
Affinity Capture-MS Homo sapiens
117 MYCN  
Affinity Capture-MS Homo sapiens
118 PRR3  
Affinity Capture-MS Homo sapiens
119 MRPL52  
Affinity Capture-MS Homo sapiens
120 MRPL19 9801
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
121 MTG1  
Proximity Label-MS Homo sapiens
122 RPA3 6119
Proximity Label-MS Homo sapiens
123 DHX30 22907
Proximity Label-MS Homo sapiens
124 TSFM 10102
Proximity Label-MS Homo sapiens
125 HSPA1A 3303
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
126 ACAD9 28976
Proximity Label-MS Homo sapiens
127 Rpl35 66489
Affinity Capture-MS Mus musculus
128 MRPL38  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
129 MRPL46  
Affinity Capture-MS Homo sapiens
130 METTL15  
Proximity Label-MS Homo sapiens
131 ZC3H3  
Affinity Capture-MS Homo sapiens
132 PFDN5 5204
Two-hybrid Homo sapiens
133 MCUR1 63933
Proximity Label-MS Homo sapiens
134 MRPL18 29074
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 FAM120A 23196
Affinity Capture-MS Homo sapiens
136 C12orf65  
Proximity Label-MS Homo sapiens
137 RPL13 6137
Affinity Capture-MS Homo sapiens
138 YBX1 4904
Affinity Capture-MS Homo sapiens
139 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
140 MRPL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 C17orf80 55028
Proximity Label-MS Homo sapiens
142 FAU 2197
Affinity Capture-MS Homo sapiens
143 MRPL33  
Affinity Capture-MS Homo sapiens
144 METTL17  
Proximity Label-MS Homo sapiens
145 AUH 549
Proximity Label-MS Homo sapiens
146 PDGFB  
Affinity Capture-MS Homo sapiens
147 ILF3 3609
Co-fractionation Homo sapiens
148 FBXL6  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
149 RPL6 6128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 GPI 2821
Co-fractionation Homo sapiens
151 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
152 APOBEC3D  
Affinity Capture-MS Homo sapiens
153 LONP1 9361
Proximity Label-MS Homo sapiens
154 FOXB1  
Affinity Capture-MS Homo sapiens
155 MRPL53  
Affinity Capture-MS Homo sapiens
156 PDHA1 5160
Proximity Label-MS Homo sapiens
157 SQSTM1 8878
Proximity Label-MS Homo sapiens
158 G3BP1 10146
Affinity Capture-MS Homo sapiens
159 UTP23  
Affinity Capture-MS Homo sapiens
160 COX8A  
Proximity Label-MS Homo sapiens
161 C21orf33  
Proximity Label-MS Homo sapiens
162 MKI67  
Affinity Capture-MS Homo sapiens
163 SSBP1 6742
Proximity Label-MS Homo sapiens
164 FASTKD3  
Proximity Label-MS Homo sapiens
165 LIN28B  
Affinity Capture-MS Homo sapiens
166 NEIL1  
Affinity Capture-MS Homo sapiens
167 GFM1 85476
Proximity Label-MS Homo sapiens
168 AARS2  
Proximity Label-MS Homo sapiens
169 Pip4k2c  
Affinity Capture-MS Mus musculus
170 TEFM  
Proximity Label-MS Homo sapiens
171 GLI4  
Affinity Capture-MS Homo sapiens
172 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 GRSF1 2926
Proximity Label-MS Homo sapiens
174 C1QBP 708
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
175 HNRNPU 3192
Affinity Capture-MS Homo sapiens
176 ZNF331  
Affinity Capture-MS Homo sapiens
177 PTRF 284119
Two-hybrid Homo sapiens
178 C8orf82  
Proximity Label-MS Homo sapiens
179 MRPL28 10573
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 MRPS18A  
Affinity Capture-MS Homo sapiens
181 DDX28  
Proximity Label-MS Homo sapiens
182 RPL17 6139
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MRPL45 is involved
No pathways found





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