Gene description for ZC3H4
Gene name zinc finger CCCH-type containing 4
Gene symbol ZC3H4
Other names/aliases C19orf7
Species Homo sapiens
 Database cross references - ZC3H4
ExoCarta ExoCarta_23211
Vesiclepedia VP_23211
Entrez Gene 23211
HGNC 17808
UniProt Q9UPT8  
 ZC3H4 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ZC3H4
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    DNA-templated transcription termination GO:0006353 IEA
    negative regulation of DNA-templated transcription, elongation GO:0032785 IDA
    nuclear RNA surveillance GO:0071027 IDA
    lncRNA catabolic process GO:0110064 IDA
    negative regulation of lncRNA transcription GO:0140744 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    chromosome GO:0005694 IEA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified ZC3H4 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZC3H4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF24  
Affinity Capture-MS Homo sapiens
2 RPL13A 23521
Affinity Capture-MS Homo sapiens
3 ANAPC15  
Affinity Capture-MS Homo sapiens
4 ACTC1 70
Proximity Label-MS Homo sapiens
5 DBN1 1627
Co-fractionation Homo sapiens
6 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 DBX2  
Affinity Capture-MS Homo sapiens
8 MARC1  
Co-fractionation Homo sapiens
9 ANKRD50 57182
Affinity Capture-MS Homo sapiens
10 EFCAB13  
Affinity Capture-MS Homo sapiens
11 OBSL1 23363
Affinity Capture-MS Homo sapiens
12 EZH1  
Affinity Capture-MS Homo sapiens
13 PEA15 8682
Affinity Capture-MS Homo sapiens
14 GAGE2E 26749
Affinity Capture-MS Homo sapiens
15 SDHAP2  
Affinity Capture-MS Homo sapiens
16 WIZ 58525
Co-fractionation Homo sapiens
17 MECP2 4204
Affinity Capture-MS Homo sapiens
18 Wdr82  
Affinity Capture-MS Mus musculus
19 MYCN  
Affinity Capture-MS Homo sapiens
20 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
21 RBM14 10432
Affinity Capture-MS Homo sapiens
22 AIF1  
Affinity Capture-MS Homo sapiens
23 DDX55  
Affinity Capture-MS Homo sapiens
24 ZC3H6  
Negative Genetic Homo sapiens
25 JMJD6 23210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SLC25A10 1468
Co-fractionation Homo sapiens
27 C20orf197  
Affinity Capture-MS Homo sapiens
28 TMEM14B  
Affinity Capture-MS Homo sapiens
29 MRPL45 84311
Co-fractionation Homo sapiens
30 CUL3 8452
Affinity Capture-MS Homo sapiens
31 SHMT1 6470
Co-fractionation Homo sapiens
32 SUPT5H 6829
Affinity Capture-MS Homo sapiens
33 RBM4B  
Affinity Capture-MS Homo sapiens
34 TUFM 7284
Proximity Label-MS Homo sapiens
35 PURG  
Affinity Capture-MS Homo sapiens
36 IFI27L1  
Affinity Capture-MS Homo sapiens
37 CBX3 11335
Proximity Label-MS Homo sapiens
38 PTP4A3  
Affinity Capture-MS Homo sapiens
39 SNRPB 6628
Affinity Capture-MS Homo sapiens
40 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 NTRK1 4914
Affinity Capture-MS Homo sapiens
42 RAD18  
Affinity Capture-MS Homo sapiens
43 FLNB 2317
Co-fractionation Homo sapiens
44 CAPN1 823
Affinity Capture-MS Homo sapiens
45 MAGEB2 4113
Affinity Capture-MS Homo sapiens
46 USP28 57646
Co-fractionation Homo sapiens
47 C1orf189  
Affinity Capture-MS Homo sapiens
48 WDR82 80335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
49 TPX2  
Affinity Capture-MS Homo sapiens
50 BACE2 25825
Affinity Capture-MS Homo sapiens
51 FURIN 5045
Affinity Capture-MS Homo sapiens
52 SDHA 6389
Co-fractionation Homo sapiens
53 PSENEN  
Affinity Capture-MS Homo sapiens
54 MRPS11  
Affinity Capture-MS Homo sapiens
55 Kifc1  
Affinity Capture-MS Mus musculus
56 MEX3A  
Affinity Capture-RNA Homo sapiens
57 ERLEC1 27248
Affinity Capture-MS Homo sapiens
58 PSMA2 5683
Co-fractionation Homo sapiens
59 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
60 HNRNPA1 3178
Proximity Label-MS Homo sapiens
61 FUS 2521
Affinity Capture-MS Homo sapiens
62 POLR2A 5430
Protein-peptide Homo sapiens
63 C21orf59 56683
Affinity Capture-MS Homo sapiens
64 CDC42 998
Affinity Capture-MS Homo sapiens
65 MYC  
Affinity Capture-MS Homo sapiens
66 XRCC6 2547
Proximity Label-MS Homo sapiens
67 Mis12  
Affinity Capture-MS Mus musculus
68 TOP1 7150
Affinity Capture-MS Homo sapiens
69 DPM2 8818
Affinity Capture-MS Homo sapiens
70 RNF2  
Affinity Capture-MS Homo sapiens
71 BMI1  
Affinity Capture-MS Homo sapiens
72 BRD3 8019
Affinity Capture-MS Homo sapiens
73 MALL  
Affinity Capture-MS Homo sapiens
74 MTERF3  
Proximity Label-MS Homo sapiens
75 MAPKAPK2 9261
Affinity Capture-MS Homo sapiens
76 PAF1 54623
Co-fractionation Homo sapiens
77 PDGFB  
Affinity Capture-MS Homo sapiens
78 CPSF6 11052
Affinity Capture-MS Homo sapiens
79 RSPH9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 Ppp1r10  
Affinity Capture-MS Mus musculus
81 SAA1 6288
Affinity Capture-MS Homo sapiens
82 MEN1 4221
Affinity Capture-MS Homo sapiens
83 SNRPA 6626
Affinity Capture-MS Homo sapiens
84 IFI6  
Affinity Capture-MS Homo sapiens
85 CAPN13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 DDX58 23586
Affinity Capture-RNA Homo sapiens
87 DYNC1H1 1778
Co-fractionation Homo sapiens
88 DHX40  
Proximity Label-MS Homo sapiens
89 MIF 4282
Affinity Capture-MS Homo sapiens
90 NUP50 10762
Proximity Label-MS Homo sapiens
91 HNRNPL 3191
Affinity Capture-MS Homo sapiens
92 GAGE5  
Affinity Capture-MS Homo sapiens
93 ZNF677  
Affinity Capture-MS Homo sapiens
94 EHHADH 1962
Affinity Capture-MS Homo sapiens
95 CYCS 54205
Affinity Capture-MS Homo sapiens
96 AR 367
Proximity Label-MS Homo sapiens
97 RC3H1 149041
Affinity Capture-MS Homo sapiens
98 SSRP1 6749
Affinity Capture-MS Homo sapiens
99 PRMT1 3276
Affinity Capture-MS Homo sapiens
100 UQCR11  
Affinity Capture-MS Homo sapiens
101 EP300 2033
Affinity Capture-MS Homo sapiens
102 HTRA4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZC3H4 is involved
No pathways found





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