Gene description for MRPL23
Gene name mitochondrial ribosomal protein L23
Gene symbol MRPL23
Other names/aliases L23MRP
RPL23
RPL23L
Species Homo sapiens
 Database cross references - MRPL23
ExoCarta ExoCarta_6150
Vesiclepedia VP_6150
Entrez Gene 6150
HGNC 10322
MIM 600789
UniProt Q16540  
 MRPL23 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL23
Molecular Function
    RNA binding GO:0003723 TAS
    structural constituent of ribosome GO:0003735 IBA
    protein binding GO:0005515 IPI
Biological Process
    translation GO:0006412 TAS
    mitochondrial translation GO:0032543 IBA
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    fibrillar center GO:0001650 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial large ribosomal subunit GO:0005762 IBA
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL23 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 KIF23 9493
Affinity Capture-MS Homo sapiens
3 MRPL24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MRPL48  
Affinity Capture-MS Homo sapiens
5 DNAJA3 9093
Proximity Label-MS Homo sapiens
6 RPS3A 6189
Co-fractionation Homo sapiens
7 RPL13 6137
Affinity Capture-MS Homo sapiens
8 MRPL30  
Affinity Capture-MS Homo sapiens
9 MRPL33  
Affinity Capture-MS Homo sapiens
10 TRUB2  
Proximity Label-MS Homo sapiens
11 MTG2  
Proximity Label-MS Homo sapiens
12 NGRN  
Proximity Label-MS Homo sapiens
13 RPL10 6134
Affinity Capture-MS Homo sapiens
14 CHCHD1  
Proximity Label-MS Homo sapiens
15 MRPL10 124995
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MRPL27 51264
Affinity Capture-MS Homo sapiens
17 MCCC1 56922
Affinity Capture-MS Homo sapiens
18 NENF 29937
Co-fractionation Homo sapiens
19 HNRNPR 10236
Co-fractionation Homo sapiens
20 RPUSD4 84881
Proximity Label-MS Homo sapiens
21 MRPL49 740
Affinity Capture-MS Homo sapiens
22 DNAJC15  
Proximity Label-MS Homo sapiens
23 MTRF1  
Proximity Label-MS Homo sapiens
24 H1FNT  
Affinity Capture-MS Homo sapiens
25 ILF2 3608
Co-fractionation Homo sapiens
26 LRPPRC 10128
Proximity Label-MS Homo sapiens
27 KIAA1429 25962
Affinity Capture-MS Homo sapiens
28 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
29 PNMA1 9240
Two-hybrid Homo sapiens
30 RPS20 6224
Co-fractionation Homo sapiens
31 MRPL20 55052
Affinity Capture-MS Homo sapiens
32 TFAM 7019
Proximity Label-MS Homo sapiens
33 PRKCDBP 112464
Co-fractionation Homo sapiens
34 PMPCA 23203
Proximity Label-MS Homo sapiens
35 HINT2 84681
Proximity Label-MS Homo sapiens
36 HARS2 23438
Affinity Capture-MS Homo sapiens
37 CDH2 1000
Co-fractionation Homo sapiens
38 SMYD3 64754
Affinity Capture-MS Homo sapiens
39 C8orf82  
Proximity Label-MS Homo sapiens
40 MRPL12 6182
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
41 CHCHD10  
Affinity Capture-MS Homo sapiens
42 MRPL57  
Affinity Capture-MS Homo sapiens
43 MRPS26 64949
Proximity Label-MS Homo sapiens
44 MALSU1  
Affinity Capture-MS Homo sapiens
45 EXD2  
Proximity Label-MS Homo sapiens
46 MRPL39 54148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ABT1 29777
Affinity Capture-MS Homo sapiens
48 NDUFAB1 4706
Two-hybrid Homo sapiens
49 ABCC2 1244
Co-fractionation Homo sapiens
50 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
51 PMPCB 9512
Proximity Label-MS Homo sapiens
52 MRPL4 51073
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 ACSF2 80221
Affinity Capture-MS Homo sapiens
54 Ccser2  
Affinity Capture-MS Mus musculus
55 VWA8 23078
Proximity Label-MS Homo sapiens
56 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 RPL19 6143
Affinity Capture-MS Homo sapiens
58 MTERF3  
Proximity Label-MS Homo sapiens
59 CBWD1 55871
Affinity Capture-MS Homo sapiens
60 MDH2 4191
Proximity Label-MS Homo sapiens
61 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 E2F4  
Affinity Capture-MS Homo sapiens
63 MRPL13  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
64 MRPS25 64432
Affinity Capture-MS Homo sapiens
65 DLD 1738
Co-fractionation Homo sapiens
66 MRPL32 64983
Affinity Capture-MS Homo sapiens
67 MPV17 4358
Co-fractionation Homo sapiens
68 C6orf203  
Proximity Label-MS Homo sapiens
69 MRPL17  
Affinity Capture-MS Homo sapiens
70 MRPL35  
Affinity Capture-MS Homo sapiens
71 MRPL45 84311
Affinity Capture-MS Homo sapiens
72 ALDH5A1 7915
Affinity Capture-MS Homo sapiens
73 YBX2 51087
Affinity Capture-MS Homo sapiens
74 PPT2  
Co-fractionation Homo sapiens
75 CPS1 1373
Affinity Capture-MS Homo sapiens
76 TUFM 7284
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
77 HSCB 150274
Proximity Label-MS Homo sapiens
78 NDUFAF5  
Affinity Capture-MS Homo sapiens
79 CYSRT1 375791
Two-hybrid Homo sapiens
80 MRPL18 29074
Affinity Capture-MS Homo sapiens
81 GFM1 85476
Proximity Label-MS Homo sapiens
82 ASB10  
Two-hybrid Homo sapiens
83 MRPL3  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
84 NARS2  
Affinity Capture-MS Homo sapiens
85 RPS6 6194
Affinity Capture-MS Homo sapiens
86 MRPL11 65003
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 MTRF1L  
Proximity Label-MS Homo sapiens
88 TMEM70  
Proximity Label-MS Homo sapiens
89 MRPL2 51069
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
90 MRPL41 64975
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 TXN2 25828
Co-fractionation Homo sapiens
92 OXA1L  
Co-fractionation Homo sapiens
93 MRPL44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 MRPL51 51258
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
95 MRPL40 64976
Affinity Capture-MS Homo sapiens
96 MRPL21 219927
Affinity Capture-MS Homo sapiens
97 MRRF  
Proximity Label-MS Homo sapiens
98 Cd2ap 12488
Affinity Capture-MS Mus musculus
99 MRPS12  
Proximity Label-MS Homo sapiens
100 MRPL46  
Affinity Capture-MS Homo sapiens
101 MTIF2 4528
Proximity Label-MS Homo sapiens
102 RPS2 6187
Co-fractionation Homo sapiens
103 PNPT1 87178
Affinity Capture-MS Homo sapiens
104 NR3C1 2908
Proximity Label-MS Homo sapiens
105 RC3H2  
Affinity Capture-MS Homo sapiens
106 YBX1 4904
Affinity Capture-MS Homo sapiens
107 MTIF3  
Proximity Label-MS Homo sapiens
108 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
109 MRPL9 65005
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 MRPS14  
Co-fractionation Homo sapiens
111 MRPL16  
Affinity Capture-MS Homo sapiens
112 RPL37 6167
Affinity Capture-MS Homo sapiens
113 TCF3  
Affinity Capture-MS Homo sapiens
114 COQ4  
Affinity Capture-MS Homo sapiens
115 TOP3A  
Affinity Capture-MS Homo sapiens
116 GADD45GIP1  
Affinity Capture-MS Homo sapiens
117 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 RIPK4  
Affinity Capture-MS Homo sapiens
119 C17orf80 55028
Proximity Label-MS Homo sapiens
120 MRPL15 29088
Affinity Capture-MS Homo sapiens
121 C12orf65  
Proximity Label-MS Homo sapiens
122 MYCN  
Affinity Capture-MS Homo sapiens
123 MRPL52  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
124 TACO1  
Proximity Label-MS Homo sapiens
125 MTG1  
Proximity Label-MS Homo sapiens
126 MYC  
Affinity Capture-MS Homo sapiens
127 MRPL37 51253
Affinity Capture-MS Homo sapiens
128 TSFM 10102
Proximity Label-MS Homo sapiens
129 MRPL1  
Affinity Capture-MS Homo sapiens
130 ACAD9 28976
Proximity Label-MS Homo sapiens
131 MRPL38  
Affinity Capture-MS Homo sapiens
132 METTL15  
Proximity Label-MS Homo sapiens
133 RBMS2 5939
Affinity Capture-MS Homo sapiens
134 SOX2  
Affinity Capture-MS Homo sapiens
135 ZNF574  
Affinity Capture-MS Homo sapiens
136 KRTAP3-3  
Two-hybrid Homo sapiens
137 CLPP 8192
Proximity Label-MS Homo sapiens
138 CS 1431
Proximity Label-MS Homo sapiens
139 MRPL42  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
140 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
141 FBXW11  
Affinity Capture-MS Homo sapiens
142 RC3H1 149041
Affinity Capture-MS Homo sapiens
143 AUH 549
Proximity Label-MS Homo sapiens
144 RPS3 6188
Co-fractionation Homo sapiens
145 ILF3 3609
Co-fractionation Homo sapiens
146 MRPL22  
Affinity Capture-MS Homo sapiens
147 GTPBP6  
Affinity Capture-MS Homo sapiens
148 ICT1 3396
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
149 SPP1 6696
Two-hybrid Homo sapiens
150 LONP1 9361
Affinity Capture-MS Homo sapiens
151 USP36  
Affinity Capture-MS Homo sapiens
152 MRPL53  
Affinity Capture-MS Homo sapiens
153 BCKDHA 593
Affinity Capture-MS Homo sapiens
154 PDHA1 5160
Affinity Capture-MS Homo sapiens
155 HNRNPM 4670
Co-fractionation Homo sapiens
156 SQSTM1 8878
Proximity Label-MS Homo sapiens
157 USP44  
Affinity Capture-MS Homo sapiens
158 KRTAP1-1  
Two-hybrid Homo sapiens
159 MRPS10 55173
Co-fractionation Homo sapiens
160 MTHFD1 4522
Co-fractionation Homo sapiens
161 C21orf33  
Proximity Label-MS Homo sapiens
162 HNRNPK 3190
Co-fractionation Homo sapiens
163 SSBP1 6742
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
164 JAK3 3718
Affinity Capture-MS Homo sapiens
165 NEIL1  
Affinity Capture-MS Homo sapiens
166 TBRG4 9238
Proximity Label-MS Homo sapiens
167 TEFM  
Proximity Label-MS Homo sapiens
168 RPL23 9349
Co-fractionation Homo sapiens
169 FECH 2235
Affinity Capture-MS Homo sapiens
170 MRPL19 9801
Affinity Capture-MS Homo sapiens
171 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 RPL8 6132
Co-fractionation Homo sapiens
173 RPS15 6209
Co-fractionation Homo sapiens
174 GRSF1 2926
Proximity Label-MS Homo sapiens
175 C1QBP 708
Proximity Label-MS Homo sapiens
176 RPL23A 6147
Affinity Capture-MS Homo sapiens
177 HNRNPU 3192
Co-fractionation Homo sapiens
178 MRPL55  
Co-fractionation Homo sapiens
179 METTL17  
Proximity Label-MS Homo sapiens
180 MRPL28 10573
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
181 MRPS18A  
Affinity Capture-MS Homo sapiens
182 MRPL43 84545
Affinity Capture-MS Homo sapiens
183 MRPS9 64965
Co-fractionation Homo sapiens
184 RPL17 6139
Affinity Capture-MS Homo sapiens
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