Gene description for SMYD3
Gene name SET and MYND domain containing 3
Gene symbol SMYD3
Other names/aliases KMT3E
ZMYND1
ZNFN3A1
bA74P14.1
Species Homo sapiens
 Database cross references - SMYD3
ExoCarta ExoCarta_64754
Vesiclepedia VP_64754
Entrez Gene 64754
HGNC 15513
MIM 608783
UniProt Q9H7B4  
 SMYD3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SMYD3
Molecular Function
    metal ion binding GO:0046872 IEA
    histone-lysine N-methyltransferase activity GO:0018024 ISS
Biological Process
    histone lysine methylation GO:0034968 IEA
    chromatin organization GO:0006325 TAS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified SMYD3 in exosomes
1
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMYD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PBX2  
Affinity Capture-MS Homo sapiens
2 HIST3H3 8290
Biochemical Activity Homo sapiens
3 HELZ 9931
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 MEST 4232
Affinity Capture-MS Homo sapiens
6 POLR2A 5430
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SMYD3 is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





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