Gene description for HELZ
Gene name helicase with zinc finger
Gene symbol HELZ
Other names/aliases DHRC
DRHC
HUMORF5
Species Homo sapiens
 Database cross references - HELZ
ExoCarta ExoCarta_9931
Vesiclepedia VP_9931
Entrez Gene 9931
HGNC 16878
MIM 606699
 HELZ identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HELZ
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    helicase activity GO:0004386 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    hydrolase activity GO:0016787 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    regulatory ncRNA-mediated post-transcriptional gene silencing GO:0035194 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IBA
    membrane GO:0016020 HDA
    P granule GO:0043186 IBA
 Experiment description of studies that identified HELZ in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HELZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUPL2 11097
Affinity Capture-MS Homo sapiens
2 PCGF5  
Affinity Capture-MS Homo sapiens
3 SLFN11 91607
Affinity Capture-MS Homo sapiens
4 C15orf39  
Affinity Capture-MS Homo sapiens
5 STAT5A 6776
Two-hybrid Homo sapiens
6 CTBP2 1488
Affinity Capture-MS Homo sapiens
7 TARDBP 23435
Affinity Capture-MS Homo sapiens
8 FBXL19  
Affinity Capture-MS Homo sapiens
9 C15orf41  
Affinity Capture-MS Homo sapiens
10 EYA2  
Proximity Label-MS Homo sapiens
11 LOXL4 84171
Affinity Capture-MS Homo sapiens
12 AIM1L  
Affinity Capture-MS Homo sapiens
13 ARID3B  
Affinity Capture-MS Homo sapiens
14 FBRS 64319
Affinity Capture-MS Homo sapiens
15 THSD4 79875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SOX2  
Affinity Capture-MS Homo sapiens
17 TTC30B  
Affinity Capture-MS Homo sapiens
18 CELA3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EIF4ENIF1 56478
Affinity Capture-MS Homo sapiens
20 KRTAP19-7  
Affinity Capture-MS Homo sapiens
21 RPS20 6224
Proximity Label-MS Homo sapiens
22 ERF  
Affinity Capture-MS Homo sapiens
23 TRMU  
Affinity Capture-MS Homo sapiens
24 TRNAU1AP  
Affinity Capture-MS Homo sapiens
25 D2HGDH 728294
Affinity Capture-MS Homo sapiens
26 SMYD3 64754
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
27 B4GALT2  
Affinity Capture-MS Homo sapiens
28 MLST8 64223
Affinity Capture-MS Homo sapiens
29 GUSBP5  
Affinity Capture-MS Homo sapiens
30 ARID3A  
Affinity Capture-MS Homo sapiens
31 HCFC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SF3B3 23450
Affinity Capture-MS Homo sapiens
33 ESRP1 54845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 POLR2C 5432
Proximity Label-MS Homo sapiens
35 KLHL20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NPAS1  
Affinity Capture-MS Homo sapiens
37 C9orf163  
Affinity Capture-MS Homo sapiens
38 KIF14 9928
Affinity Capture-MS Homo sapiens
39 LIN28A  
Affinity Capture-MS Homo sapiens
40 NUP155 9631
Proximity Label-MS Homo sapiens
41 RB1 5925
Affinity Capture-MS Homo sapiens
42 KRT8 3856
Proximity Label-MS Homo sapiens
43 FAM96A  
Affinity Capture-MS Homo sapiens
44 POM121C  
Affinity Capture-MS Homo sapiens
45 SULT1C4  
Affinity Capture-MS Homo sapiens
46 P4HA1 5033
Affinity Capture-MS Homo sapiens
47 CHIA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CTDP1 9150
Affinity Capture-MS Homo sapiens
49 PARK2  
Affinity Capture-MS Homo sapiens
50 CTBP1 1487
Affinity Capture-MS Homo sapiens
51 LY6G5B  
Affinity Capture-MS Homo sapiens
52 PPP4R1L  
Affinity Capture-MS Homo sapiens
53 RBM4B  
Affinity Capture-MS Homo sapiens
54 ANGPTL7 10218
Affinity Capture-MS Homo sapiens
55 PURG  
Affinity Capture-MS Homo sapiens
56 TRMT61A 115708
Affinity Capture-MS Homo sapiens
57 PAN2  
Affinity Capture-MS Homo sapiens
58 AKAP1 8165
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 LRRC29  
Affinity Capture-MS Homo sapiens
60 PIGT 51604
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 IFI16 3428
Affinity Capture-MS Homo sapiens
62 F12  
Affinity Capture-MS Homo sapiens
63 SOWAHA  
Affinity Capture-MS Homo sapiens
64 CELA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 HSPB8 26353
Affinity Capture-MS Homo sapiens
66 UBXN6 80700
Affinity Capture-MS Homo sapiens
67 RBL1  
Affinity Capture-MS Homo sapiens
68 TNXB 7148
Affinity Capture-MS Homo sapiens
69 GAN 8139
Affinity Capture-MS Homo sapiens
70 HSD3B7 80270
Proximity Label-MS Homo sapiens
71 AGBL4  
Affinity Capture-MS Homo sapiens
72 PAN3 255967
Affinity Capture-MS Homo sapiens
73 KIF20A 10112
Affinity Capture-MS Homo sapiens
74 RC3H2  
Affinity Capture-MS Homo sapiens
75 RBM47 54502
Affinity Capture-MS Homo sapiens
76 SH3YL1  
Two-hybrid Homo sapiens
77 SIRT7  
Affinity Capture-MS Homo sapiens
78 PHIP 55023
Affinity Capture-MS Homo sapiens
79 SLC25A48  
Affinity Capture-MS Homo sapiens
80 CCNJL  
Affinity Capture-MS Homo sapiens
81 DUSP16  
Affinity Capture-MS Homo sapiens
82 KIAA0430  
Affinity Capture-MS Homo sapiens
83 NXF1 10482
Affinity Capture-RNA Homo sapiens
84 NXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 FASN 2194
Negative Genetic Homo sapiens
86 ABTB2 25841
Affinity Capture-MS Homo sapiens
87 C12orf74  
Affinity Capture-MS Homo sapiens
88 MYC  
Affinity Capture-MS Homo sapiens
89 RPA3 6119
Proximity Label-MS Homo sapiens
90 SOHLH1  
Affinity Capture-MS Homo sapiens
91 SAV1  
Proximity Label-MS Homo sapiens
92 SEC16A 9919
Affinity Capture-MS Homo sapiens
93 PABPC5 140886
Affinity Capture-MS Homo sapiens
94 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
95 CLASRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 KLHL10  
Affinity Capture-MS Homo sapiens
97 KIAA1671  
Affinity Capture-MS Homo sapiens
98 RNF2  
Affinity Capture-MS Homo sapiens
99 BMI1  
Affinity Capture-MS Homo sapiens
100 CLTC 1213
Affinity Capture-MS Homo sapiens
101 NUP35 129401
Proximity Label-MS Homo sapiens
102 DUSP18  
Proximity Label-MS Homo sapiens
103 EBF3  
Affinity Capture-MS Homo sapiens
104 RBMS2 5939
Affinity Capture-MS Homo sapiens
105 METTL21B  
Affinity Capture-MS Homo sapiens
106 Lgals3bp 19039
Affinity Capture-MS Mus musculus
107 ZRANB1 54764
Affinity Capture-MS Homo sapiens
108 RNF43  
Proximity Label-MS Homo sapiens
109 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
110 FBXW11  
Affinity Capture-MS Homo sapiens
111 NSUN5P1  
Affinity Capture-MS Homo sapiens
112 SWSAP1  
Affinity Capture-MS Homo sapiens
113 GRB2 2885
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
114 L3HYPDH 112849
Affinity Capture-MS Homo sapiens
115 TUBG1 7283
Affinity Capture-MS Homo sapiens
116 APOBEC3D  
Affinity Capture-MS Homo sapiens
117 WRAP53  
Affinity Capture-MS Homo sapiens
118 SQSTM1 8878
Proximity Label-MS Homo sapiens
119 MKRN3  
Affinity Capture-MS Homo sapiens
120 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
121 CREBBP  
Affinity Capture-MS Homo sapiens
122 CRYBB3  
Affinity Capture-MS Homo sapiens
123 NISCH 11188
Affinity Capture-MS Homo sapiens
124 CPEB1  
Proximity Label-MS Homo sapiens
125 ERGIC1 57222
Proximity Label-MS Homo sapiens
126 PCGF3  
Affinity Capture-MS Homo sapiens
127 RCBTB1  
Affinity Capture-MS Homo sapiens
128 RBFOX2 23543
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 NUP50 10762
Affinity Capture-MS Homo sapiens
130 NEIL1  
Affinity Capture-MS Homo sapiens
131 DHFR 1719
Affinity Capture-MS Homo sapiens
132 EYA4 2070
Affinity Capture-MS Homo sapiens
133 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
134 PXN 5829
Proximity Label-MS Homo sapiens
135 WDR90  
Affinity Capture-MS Homo sapiens
136 SHARPIN  
Affinity Capture-MS Homo sapiens
137 SERBP1 26135
Proximity Label-MS Homo sapiens
138 PRKAG3  
Affinity Capture-MS Homo sapiens
139 GNB2L1 10399
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 RC3H1 149041
Affinity Capture-MS Homo sapiens
141 POM121  
Affinity Capture-MS Homo sapiens
142 CCT8L2  
Affinity Capture-MS Homo sapiens
143 BCAT1 586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 ECSIT 51295
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HELZ is involved
No pathways found





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