Gene description for THSD4
Gene name thrombospondin, type I, domain containing 4
Gene symbol THSD4
Other names/aliases ADAMTSL-6
ADAMTSL6
FVSY9334
PRO34005
Species Homo sapiens
 Database cross references - THSD4
ExoCarta ExoCarta_79875
Entrez Gene 79875
HGNC 25835
MIM 614476
UniProt Q6ZMP0  
 THSD4 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for THSD4
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
Biological Process
    proteolysis GO:0006508 IEA
    elastic fiber assembly GO:0048251 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    microfibril GO:0001527 IEA
 Experiment description of studies that identified THSD4 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for THSD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which THSD4 is involved
PathwayEvidenceSource
O-glycosylation of TSR domain-containing proteins TAS Reactome





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