Gene description for RPL37
Gene name ribosomal protein L37
Gene symbol RPL37
Other names/aliases L37
Species Homo sapiens
 Database cross references - RPL37
ExoCarta ExoCarta_6167
Vesiclepedia VP_6167
Entrez Gene 6167
HGNC 10347
MIM 604181
UniProt P61927  
 RPL37 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for RPL37
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 TAS
    structural constituent of ribosome GO:0003735 IDA
    structural constituent of ribosome GO:0003735 NAS
    structural constituent of ribosome GO:0003735 TAS
    rRNA binding GO:0019843 IEA
    metal ion binding GO:0046872 IEA
    MDM2/MDM4 family protein binding GO:0097371 IPI
    ubiquitin ligase inhibitor activity GO:1990948 IDA
Biological Process
    cytoplasmic translation GO:0002181 IC
    cytoplasmic translation GO:0002181 NAS
    translation GO:0006412 NAS
    translation GO:0006412 TAS
    positive regulation of signal transduction by p53 class mediator GO:1901798 IDA
Subcellular Localization
    cytoplasm GO:0005737 NAS
    cytosol GO:0005829 TAS
    cytosolic large ribosomal subunit GO:0022625 HDA
    cytosolic large ribosomal subunit GO:0022625 IBA
    cytosolic large ribosomal subunit GO:0022625 IDA
    cytosolic large ribosomal subunit GO:0022625 IPI
    cytosolic large ribosomal subunit GO:0022625 TAS
    cytosolic ribosome GO:0022626 IDA
    synapse GO:0045202 IEA
 Experiment description of studies that identified RPL37 in exosomes
1
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
4
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RPL37
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 RPL26L1 51121
Affinity Capture-MS Homo sapiens
3 MRPL48  
Affinity Capture-MS Homo sapiens
4 MRPL30  
Affinity Capture-MS Homo sapiens
5 RPL30 6156
Co-fractionation Homo sapiens
6 RPL37A 6168
Co-fractionation Homo sapiens
7 ABL1 25
Affinity Capture-MS Homo sapiens
8 RPL9 6133
Co-fractionation Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 MRPL37 51253
Affinity Capture-MS Homo sapiens
11 MRPL27 51264
Affinity Capture-MS Homo sapiens
12 MRPL50 54534
Affinity Capture-MS Homo sapiens
13 DHX57 90957
Affinity Capture-MS Homo sapiens
14 MRPL49 740
Affinity Capture-MS Homo sapiens
15 APP 351
Reconstituted Complex Homo sapiens
16 RPS3 6188
Co-fractionation Homo sapiens
17 USP36  
Affinity Capture-MS Homo sapiens
18 MRPL20 55052
Affinity Capture-MS Homo sapiens
19 MRPL23 6150
Affinity Capture-MS Homo sapiens
20 PRC1 9055
Affinity Capture-MS Homo sapiens
21 NPM1 4869
Affinity Capture-MS Homo sapiens
22 OBSL1 23363
Affinity Capture-MS Homo sapiens
23 RPS9 6203
Co-fractionation Homo sapiens
24 MRS2  
Affinity Capture-MS Homo sapiens
25 MRPL39 54148
Affinity Capture-MS Homo sapiens
26 RPL29 6159
Co-fractionation Homo sapiens
27 ATG16L1 55054
Affinity Capture-MS Homo sapiens
28 MRPS7 51081
Affinity Capture-MS Homo sapiens
29 WIF1 11197
Two-hybrid Homo sapiens
30 MYCN  
Affinity Capture-MS Homo sapiens
31 MRPL4 51073
Affinity Capture-MS Homo sapiens
32 RPS11 6205
Co-fractionation Homo sapiens
33 MRPL47 57129
Affinity Capture-MS Homo sapiens
34 Tmed10 68581
Affinity Capture-MS Mus musculus
35 ZNF579  
Affinity Capture-MS Homo sapiens
36 MRPS30 10884
Affinity Capture-MS Homo sapiens
37 AURKA 6790
Affinity Capture-MS Homo sapiens
38 RPL27 6155
Co-fractionation Homo sapiens
39 PHF10  
Affinity Capture-MS Homo sapiens
40 MRPL32 64983
Affinity Capture-MS Homo sapiens
41 MRPL17  
Affinity Capture-MS Homo sapiens
42 DDX21 9188
Affinity Capture-MS Homo sapiens
43 MRPL45 84311
Affinity Capture-MS Homo sapiens
44 LSM14B 149986
Affinity Capture-MS Homo sapiens
45 RPL4 6124
Co-fractionation Homo sapiens
46 YBX2 51087
Affinity Capture-MS Homo sapiens
47 BLM 641
Synthetic Growth Defect Homo sapiens
48 RTF1 23168
Co-fractionation Homo sapiens
49 RPL5 6125
Co-fractionation Homo sapiens
50 CDH1 999
Proximity Label-MS Homo sapiens
51 MRPL51 51258
Affinity Capture-MS Homo sapiens
52 MRPL22  
Affinity Capture-MS Homo sapiens
53 ZFP91 80829
Affinity Capture-MS Homo sapiens
54 MRPL11 65003
Affinity Capture-MS Homo sapiens
55 RANBP6 26953
Affinity Capture-MS Homo sapiens
56 RPS15A 6210
Co-fractionation Homo sapiens
57 SRPK1 6732
Affinity Capture-MS Homo sapiens
58 MRPL2 51069
Affinity Capture-MS Homo sapiens
59 BRD7  
Affinity Capture-MS Homo sapiens
60 MRPL44  
Affinity Capture-MS Homo sapiens
61 MRPL40 64976
Affinity Capture-MS Homo sapiens
62 IPO5 3843
Affinity Capture-MS Homo sapiens
63 MRPL21 219927
Affinity Capture-MS Homo sapiens
64 RPLP2 6181
Co-fractionation Homo sapiens
65 NKX2-5  
Affinity Capture-MS Homo sapiens
66 MRPL24  
Affinity Capture-MS Homo sapiens
67 MRPL35  
Affinity Capture-MS Homo sapiens
68 MRPL10 124995
Affinity Capture-MS Homo sapiens
69 MRPL9 65005
Affinity Capture-MS Homo sapiens
70 MRPL16  
Affinity Capture-MS Homo sapiens
71 NR3C1 2908
Proximity Label-MS Homo sapiens
72 CTTN 2017
Two-hybrid Homo sapiens
73 MRPL3  
Affinity Capture-MS Homo sapiens
74 GADD45GIP1  
Affinity Capture-MS Homo sapiens
75 ACE2 59272
Proximity Label-MS Homo sapiens
76 MDM4  
Affinity Capture-Western Homo sapiens
77 MRPL15 29088
Affinity Capture-MS Homo sapiens
78 AURKB 9212
Affinity Capture-MS Homo sapiens
79 MRPL1  
Affinity Capture-MS Homo sapiens
80 CDK2 1017
Affinity Capture-MS Homo sapiens
81 MYO1D 4642
Two-hybrid Homo sapiens
82 MFAP1  
Co-fractionation Homo sapiens
83 MYC  
Affinity Capture-MS Homo sapiens
84 RPS13 6207
Co-fractionation Homo sapiens
85 RPL35A 6165
Co-fractionation Homo sapiens
86 RPL12 6136
Co-fractionation Homo sapiens
87 GNLY  
Affinity Capture-MS Homo sapiens
88 RPL22 6146
Co-fractionation Homo sapiens
89 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
90 EIF2B1 1967
Affinity Capture-MS Homo sapiens
91 MRPL38  
Affinity Capture-MS Homo sapiens
92 ARAF 369
Affinity Capture-MS Homo sapiens
93 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 MRPL18 29074
Affinity Capture-MS Homo sapiens
95 H2AFX 3014
Affinity Capture-MS Homo sapiens
96 RPL13 6137
Co-fractionation Homo sapiens
97 MRPL42  
Affinity Capture-MS Homo sapiens
98 MAST3  
Affinity Capture-MS Homo sapiens
99 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
100 RNF220  
Affinity Capture-MS Homo sapiens
101 KIF14 9928
Affinity Capture-MS Homo sapiens
102 ILF3 3609
Affinity Capture-MS Homo sapiens
103 RPLP0 6175
Co-fractionation Homo sapiens
104 POLR1B 84172
Two-hybrid Homo sapiens
105 ICT1 3396
Affinity Capture-MS Homo sapiens
106 MRPS18C  
Affinity Capture-MS Homo sapiens
107 MRPS31  
Affinity Capture-MS Homo sapiens
108 MRPL43 84545
Affinity Capture-MS Homo sapiens
109 UBA52 7311
Co-fractionation Homo sapiens
110 SQSTM1 8878
Two-hybrid Homo sapiens
111 PBRM1 55193
Affinity Capture-MS Homo sapiens
112 RPS15 6209
Co-fractionation Homo sapiens
113 MRPL57  
Affinity Capture-MS Homo sapiens
114 MRPL13  
Affinity Capture-MS Homo sapiens
115 TCF3  
Two-hybrid Homo sapiens
116 C1QBP 708
Affinity Capture-MS Homo sapiens
117 KRAS 3845
Negative Genetic Homo sapiens
118 MRPL55  
Affinity Capture-MS Homo sapiens
119 SS18L2  
Affinity Capture-MS Homo sapiens
120 UBA6 55236
Co-fractionation Homo sapiens
121 MRPL28 10573
Affinity Capture-MS Homo sapiens
122 MRPS18A  
Affinity Capture-MS Homo sapiens
123 DDX56  
Affinity Capture-MS Homo sapiens
124 MRPS9 64965
Affinity Capture-MS Homo sapiens
125 RPL17 6139
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which RPL37 is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Cap-dependent Translation Initiation TAS Reactome
Cellular response to starvation IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Eukaryotic Translation Elongation IEA Reactome
Eukaryotic Translation Initiation TAS Reactome
Eukaryotic Translation Termination IEA Reactome
Formation of a pool of free 40S subunits TAS Reactome
GTP hydrolysis and joining of the 60S ribosomal subunit TAS Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
L13a-mediated translational silencing of Ceruloplasmin expression TAS Reactome
Major pathway of rRNA processing in the nucleolus and cytosol TAS Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Nervous system development IEA Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TAS Reactome
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) TAS Reactome
Nonsense-Mediated Decay (NMD) TAS Reactome
Peptide chain elongation IEA Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Response of EIF2AK4 (GCN2) to amino acid deficiency IEA Reactome
rRNA processing TAS Reactome
rRNA processing in the nucleus and cytosol TAS Reactome
Selenoamino acid metabolism IEA Reactome
Selenocysteine synthesis IEA Reactome
Signaling by ROBO receptors IEA Reactome
SRP-dependent cotranslational protein targeting to membrane IEA Reactome
SRP-dependent cotranslational protein targeting to membrane TAS Reactome
Translation TAS Reactome
Translation IEA Reactome
Viral Infection Pathways TAS Reactome
Viral mRNA Translation TAS Reactome





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