Gene description for SFRP4
Gene name secreted frizzled-related protein 4
Gene symbol SFRP4
Other names/aliases FRP-4
FRPHE
sFRP-4
Species Homo sapiens
 Database cross references - SFRP4
ExoCarta ExoCarta_6424
Entrez Gene 6424
HGNC 10778
MIM 606570
UniProt Q6FHJ7  
 SFRP4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SFRP4
Molecular Function
    G-protein coupled receptor activity GO:0004930 IBA
    Wnt-activated receptor activity GO:0042813 IBA
    protein binding GO:0005515 IPI
    Wnt-protein binding GO:0017147 IBA
Biological Process
    positive regulation of keratinocyte apoptotic process GO:1902174 IDA
    negative regulation of cell proliferation GO:0008285 IMP
    multicellular organismal development GO:0007275 IEA
    positive regulation of gene expression GO:0010628 IDA
    response to hormone GO:0009725 NAS
    phosphate ion homeostasis GO:0055062 IDA
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IDA
    canonical Wnt signaling pathway GO:0060070 IBA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IGI
    positive regulation of epidermal cell differentiation GO:0045606 IDA
    cell differentiation GO:0030154 IEA
    non-canonical Wnt signaling pathway GO:0035567 IBA
    positive regulation of apoptotic process GO:0043065 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    negative regulation of sodium-dependent phosphate transport GO:2000119 IDA
    positive regulation of receptor internalization GO:0002092 IDA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
Subcellular Localization
    cell surface GO:0009986 IDA
    nucleus GO:0005634 IDA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IDA
    integral component of membrane GO:0016021 IBA
 Experiment description of studies that identified SFRP4 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SFRP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SFRP4 is involved
No pathways found





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