Gene description for TOM1L1
Gene name target of myb1 (chicken)-like 1
Gene symbol TOM1L1
Other names/aliases OK/KNS-CL.3
SRCASM
Species Homo sapiens
 Database cross references - TOM1L1
ExoCarta ExoCarta_10040
Entrez Gene 10040
HGNC 11983
MIM 604701
UniProt O75674  
 TOM1L1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 25844599    
 Gene ontology annotations for TOM1L1
Molecular Function
    SH3 domain binding GO:0017124 IEA
    ubiquitin binding GO:0043130 TAS
    clathrin binding GO:0030276 IDA
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    protein kinase activator activity GO:0030295 IEA
Biological Process
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 NAS
    signal transduction GO:0007165 IDA
    positive regulation of protein autophosphorylation GO:0031954 IDA
    activation of protein kinase activity GO:0032147 IDA
    negative regulation of mitotic nuclear division GO:0045839 IDA
    intracellular protein transport GO:0006886 IEA
    regulation of DNA biosynthetic process GO:2000278 IDA
Subcellular Localization
    endosome membrane GO:0010008 IEA
    lysosome GO:0005764 TAS
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 IDA
    Golgi stack GO:0005795 IEA
    endosome GO:0005768 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified TOM1L1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for TOM1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSN 2934
Two-hybrid Homo sapiens
2 GLUD2  
Two-hybrid Homo sapiens
3 PHYH  
Two-hybrid Homo sapiens
4 COPS7A  
Two-hybrid Homo sapiens
5 PWP2H  
Two-hybrid Homo sapiens
6 NDC80 10403
Two-hybrid Homo sapiens
7 T1A-2  
Two-hybrid Homo sapiens
8 UBXD2  
Two-hybrid Homo sapiens
9 CWF19L1 55280
Two-hybrid Homo sapiens
10 PELP1 27043
Two-hybrid Homo sapiens
11 GRB2 2885
Invivo Homo sapiens
Invitro Homo sapiens
12 NOMO1 23420
Two-hybrid Homo sapiens
13 PIK3R1 5295
Invitro Homo sapiens
14 CCDC47 57003
Two-hybrid Homo sapiens
15 CELF1 10658
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TOM1L1 is involved
No pathways found





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