Gene description for KCTD20
Gene name potassium channel tetramerization domain containing 20
Gene symbol KCTD20
Other names/aliases C6orf69
dJ108K11.3
Species Homo sapiens
 Database cross references - KCTD20
ExoCarta ExoCarta_222658
Vesiclepedia VP_222658
Entrez Gene 222658
HGNC 21052
MIM 615932
UniProt Q7Z5Y7  
 KCTD20 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for KCTD20
Molecular Function
    identical protein binding GO:0042802 IEA
Biological Process
    signal transduction GO:0007165 IBA
    positive regulation of phosphorylation GO:0042327 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified KCTD20 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for KCTD20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AURKA 6790
Affinity Capture-MS Homo sapiens
2 SOX13  
Affinity Capture-MS Homo sapiens
3 PPP1CA 5499
Two-hybrid Homo sapiens
4 PPP1CC 5501
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MARK4  
Affinity Capture-MS Homo sapiens
6 HECTD1 25831
Affinity Capture-MS Homo sapiens
7 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 DDX58 23586
Affinity Capture-RNA Homo sapiens
9 Cul3  
Affinity Capture-MS Mus musculus
10 MEX3A  
Affinity Capture-RNA Homo sapiens
11 COPS7A 50813
Affinity Capture-MS Homo sapiens
12 ARRDC5  
Affinity Capture-MS Homo sapiens
13 XPO1 7514
Affinity Capture-MS Homo sapiens
14 BUB3 9184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DUSP16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KCTD20 is involved
No pathways found





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