Gene description for ATAD2B
Gene name ATPase family, AAA domain containing 2B
Gene symbol ATAD2B
Other names/aliases -
Species Homo sapiens
 Database cross references - ATAD2B
ExoCarta ExoCarta_54454
Entrez Gene 54454
HGNC 29230
MIM 615347
UniProt Q9ULI0  
 ATAD2B identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ATAD2B
Molecular Function
    lysine-acetylated histone binding GO:0070577 IDA
    ATP binding GO:0005524 IEA
    ATPase activity GO:0016887 IBA
    chromatin binding GO:0003682 IBA
Biological Process
    metabolic process GO:0008152 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    negative regulation of chromatin silencing GO:0031936 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified ATAD2B in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ATAD2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATAD2B is involved
No pathways found





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