Gene description for RLF
Gene name rearranged L-myc fusion
Gene symbol RLF
Other names/aliases ZN-15L
ZNF292L
Species Homo sapiens
 Database cross references - RLF
ExoCarta ExoCarta_6018
Vesiclepedia VP_6018
Entrez Gene 6018
HGNC 10025
MIM 180610
UniProt Q13129  
 RLF identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for RLF
Molecular Function
    zinc ion binding GO:0008270 TAS
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    DNA integration GO:0015074 IDA
    regulation of transcription, DNA-templated GO:0006355 NAS
    transcription, DNA-templated GO:0006351 IEA
    chromosome organization GO:0051276 NAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
Subcellular Localization
    nucleus GO:0005634 IC
 Experiment description of studies that identified RLF in exosomes
1
Experiment ID 226
MISEV standards
EM
EV Biophysical techniques
GAPDH|CD9|FLOT1
EV Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for RLF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNKSR2 22866
Affinity Capture-Western Homo sapiens
2 RIT2  
Reconstituted Complex Homo sapiens
3 RIT1 6016
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RLF is involved
No pathways found





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