Gene description for DNAH2
Gene name dynein, axonemal, heavy chain 2
Gene symbol DNAH2
Other names/aliases DNAHC2
DNHD3
Species Homo sapiens
 Database cross references - DNAH2
ExoCarta ExoCarta_146754
Entrez Gene 146754
HGNC 2948
MIM 603333
UniProt Q9P225  
 DNAH2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DNAH2
Molecular Function
    ATPase activity GO:0016887 IEA
    ATP binding GO:0005524 IEA
    microtubule motor activity GO:0003777 NAS
Biological Process
    cilium or flagellum-dependent cell motility GO:0001539 NAS
    microtubule-based movement GO:0007018 IEA
    metabolic process GO:0008152 NAS
Subcellular Localization
    microtubule GO:0005874 IEA
    axonemal dynein complex GO:0005858 NAS
 Experiment description of studies that identified DNAH2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DNAH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNAH2 is involved
No pathways found





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