Gene description for EPX
Gene name eosinophil peroxidase
Gene symbol EPX
Other names/aliases EPO
Species Homo sapiens
 Database cross references - EPX
ExoCarta ExoCarta_8288
Entrez Gene 8288
HGNC 3423
MIM 131399
UniProt P11678  
 EPX identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for EPX
Molecular Function
    metal ion binding GO:0046872 IEA
    heme binding GO:0020037 IEA
    peroxidase activity GO:0004601 IEA
Biological Process
    response to oxidative stress GO:0006979 IEA
    negative regulation of interleukin-5 production GO:0032714 IEA
    positive regulation of interleukin-4 production GO:0032753 IEA
    oxidation-reduction process GO:0055114 IEA
    defense response to nematode GO:0002215 IEA
    eosinophil migration GO:0072677 IEA
    hydrogen peroxide catabolic process GO:0042744 IEA
    negative regulation of interleukin-10 production GO:0032693 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified EPX in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EPX
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which EPX is involved
No pathways found

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