ExoCarta: Gene summary

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Gene description for GLYR1
Gene name	glyoxylate reductase 1 homolog (Arabidopsis)
Gene symbol	GLYR1
Other names/aliases	BM045 HIBDL N-PAC NP60
Species	Homo sapiens
Database cross references - GLYR1
ExoCarta	ExoCarta_84656
Vesiclepedia	VP_84656
Entrez Gene	84656
HGNC	24434
MIM	610660
UniProt	Q49A26
GLYR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Thymus	23844026

Gene ontology annotations for GLYR1

Molecular Function
	DNA binding	GO:0003677	IBA
	DNA binding	GO:0003677	IDA
	chromatin binding	GO:0003682	IDA
	protein binding	GO:0005515	IPI
	nucleosome binding	GO:0031491	IBA
	nucleosome binding	GO:0031491	IDA
	methylated histone binding	GO:0035064	IDA
	histone binding	GO:0042393	IDA
	NADP binding	GO:0050661	IEA
	NAD binding	GO:0051287	IEA
	chromatin-protein adaptor activity	GO:0140463	IDA
Biological Process
	transcription initiation-coupled chromatin remodeling	GO:0045815	IDA
	transcription elongation-coupled chromatin remodeling	GO:0140673	IBA
	transcription elongation-coupled chromatin remodeling	GO:0140673	IDA
Subcellular Localization
	chromatin	GO:0000785	IBA
	chromatin	GO:0000785	IDA
	nucleosome	GO:0000786	IDA
	nucleoplasm	GO:0005654	IDA
	cytosol	GO:0005829	IDA

Experiment description of studies that identified GLYR1 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

217

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|CD81\|CD9\|CD63	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23844026

Organism

Homo sapiens

Experiment description

Characterization of human thymic exosomes.

Authors

"Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."

Journal name

PLoS One

Publication year

2013

Sample

Thymus

Sample name

Normal-Thymus

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for GLYR1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

HNRNPH1

3187

Affinity Capture-RNA

Homo sapiens

CDC14B

8555

Proximity Label-MS

Homo sapiens

CAPNS2

84290

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HIST2H2BE

8349

Affinity Capture-MS

Homo sapiens

ZNF668

Affinity Capture-MS

Homo sapiens

UBE2H

7328

Affinity Capture-MS

Homo sapiens

RSL1D1

26156

Affinity Capture-MS

Homo sapiens

NOP58

51602

Co-fractionation

Homo sapiens

ZNF346

Affinity Capture-MS

Homo sapiens

RPL30

6156

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TOP2B

7155

Co-fractionation

Homo sapiens

HIST1H1D

3007

Affinity Capture-MS

Homo sapiens

LHX2

Proximity Label-MS

Homo sapiens

RPL13A

23521

Affinity Capture-MS

Homo sapiens

RPL37A

6168

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NOP56

10528

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

MAGEA1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPS19

6223

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPL14

9045

Affinity Capture-MS

Homo sapiens

PNMAL1

Affinity Capture-MS

Homo sapiens

RSBN1

Affinity Capture-MS

Homo sapiens

SOX2

Proximity Label-MS

Homo sapiens

CENPA

Proximity Label-MS

Homo sapiens

ILF2

3608

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

APEX1

328

Proximity Label-MS

Homo sapiens

GPATCH4

54865

Affinity Capture-MS

Homo sapiens

CLIC3

9022

Two-hybrid

Homo sapiens

ETV3

Proximity Label-MS

Homo sapiens

PRR11

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FNTB

2342

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FBXW7

Affinity Capture-MS

Homo sapiens

PRC1

9055

Affinity Capture-MS

Homo sapiens

NPM1

4869

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FBXW8

26259

Affinity Capture-MS

Homo sapiens

H2AFY2

55506

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

OBSL1

23363

Affinity Capture-MS

Homo sapiens

RPS9

6203

Affinity Capture-MS

Homo sapiens

SRP14

6727

Affinity Capture-MS

Homo sapiens

ADARB1

104

Affinity Capture-MS

Homo sapiens

PRKRA

8575

Affinity Capture-MS

Homo sapiens

RCC1

1104

Co-fractionation

Homo sapiens

EED

Affinity Capture-MS

Homo sapiens

DDX18

8886

Co-fractionation

Homo sapiens

RRP8

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FBL

2091

Co-fractionation

Homo sapiens

RPS3A

6189

Affinity Capture-MS

Homo sapiens

MECP2

4204

Affinity Capture-MS

Homo sapiens

MYCN

Affinity Capture-MS

Homo sapiens

RPL4

6124

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

H2AFB2

Affinity Capture-MS

Homo sapiens

ZNF2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

Lima1

Affinity Capture-MS

Mus musculus

KIF14

9928

Affinity Capture-MS

Homo sapiens

LARP4B

23185

Affinity Capture-MS

Homo sapiens

ZCRB1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FSCN1

6624

Affinity Capture-MS

Homo sapiens

LCP1

3936

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HAL

3034

Affinity Capture-MS

Homo sapiens

HIST1H4A

8359

Affinity Capture-MS

Homo sapiens

DDX21

9188

Affinity Capture-MS

Homo sapiens

TLX3

Proximity Label-MS

Homo sapiens

SRPK2

6733

Affinity Capture-MS

Homo sapiens

PLEKHO1

51177

Affinity Capture-MS

Homo sapiens

ZBTB47

Affinity Capture-MS

Homo sapiens

SRSF3

6428

Affinity Capture-MS

Homo sapiens

STAU1

6780

Affinity Capture-MS

Homo sapiens

SRSF6

6431

Affinity Capture-MS

Homo sapiens

PURG

Affinity Capture-MS

Homo sapiens

NOP2

4839

Affinity Capture-MS

Homo sapiens

HIST1H3E

8353

Affinity Capture-MS

Homo sapiens

RPL18A

6142

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NOC2L

26155

Co-fractionation

Homo sapiens

Srp72

Affinity Capture-MS

Mus musculus

FOXL2

Affinity Capture-MS

Homo sapiens

RPS10

6204

Affinity Capture-MS

Homo sapiens

FGF8

Affinity Capture-MS

Homo sapiens

IFI16

3428

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HIST1H1E

3008

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ARL16

Two-hybrid

Homo sapiens

RPL36

25873

Affinity Capture-MS

Homo sapiens

HIST1H1C

3006

Affinity Capture-MS

Homo sapiens

HIST1H2BG

8339

Proximity Label-MS

Homo sapiens

LYAR

55646

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DHX9

1660

Co-fractionation

Homo sapiens

HECTD1

25831

Affinity Capture-MS

Homo sapiens

RPLP0

6175

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SRPK3

Affinity Capture-MS

Homo sapiens

MAGEB2

4113

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CDX1

Affinity Capture-MS

Homo sapiens

MYBBP1A

10514

Affinity Capture-MS

Homo sapiens

GLTSCR2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

C6orf165

Two-hybrid

Homo sapiens

RPL11

6135

Affinity Capture-MS

Homo sapiens

WDR46

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CNBP

7555

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FGFBP1

9982

Affinity Capture-MS

Homo sapiens

NUMA1

4926

Affinity Capture-MS

Homo sapiens

STK3

6788

Affinity Capture-MS

Homo sapiens

PAX6

Proximity Label-MS

Homo sapiens

100

ZBTB2

57621

Affinity Capture-MS

Homo sapiens

101

RPL10A

4736

Affinity Capture-MS

Homo sapiens

102

RPL31

6160

Affinity Capture-MS

Homo sapiens

103

HIST1H3A

8350

Proximity Label-MS

Homo sapiens

104

ABT1

29777

Affinity Capture-MS

Homo sapiens

105

RPL7A

6130

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

106

CCNC

Two-hybrid

Homo sapiens

107

RPS2

6187

Affinity Capture-MS

Homo sapiens

108

RC3H2

Affinity Capture-MS

Homo sapiens

109

SIRT7

Affinity Capture-MS

Homo sapiens

110

SRSF4

6429

Affinity Capture-MS

Homo sapiens

111

SRSF1

6426

Affinity Capture-MS

Homo sapiens

112

MEX3A

Affinity Capture-RNA

Homo sapiens

113

NPM3

10360

Affinity Capture-MS

Homo sapiens

114

RPS6

6194

Affinity Capture-MS

Homo sapiens

115

SRSF5

6430

Affinity Capture-MS

Homo sapiens

116

RPL3

6122

Affinity Capture-MS

Homo sapiens

117

RPL35

11224

Affinity Capture-MS

Homo sapiens

118

SUZ12

Affinity Capture-MS

Homo sapiens

119

HIST3H3

8290

Protein-peptide

Homo sapiens

120

ZC3H10

Affinity Capture-MS

Homo sapiens

121

RFC1

5981

Co-fractionation

Homo sapiens

122

BLK

640

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

GEMIN4

50628

Two-hybrid

Homo sapiens

124

CUL9

Affinity Capture-MS

Homo sapiens

125

RBM4B

Affinity Capture-MS

Homo sapiens

126

MYC

Affinity Capture-MS

Homo sapiens

127

RPA3

6119

Proximity Label-MS

Homo sapiens

128

DNAJC9

23234

Proximity Label-MS

Homo sapiens

129

RNF151

Affinity Capture-MS

Homo sapiens

130

PTPRB

5787

Affinity Capture-MS

Homo sapiens

131

HIST1H1A

3024

Affinity Capture-MS

Homo sapiens

132

RPL23A

6147

Affinity Capture-MS

Homo sapiens

133

DDRGK1

65992

Affinity Capture-MS

Homo sapiens

134

RNF2

Affinity Capture-MS

Homo sapiens

135

ZC3HAV1

56829

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

136

CDKN2D

Two-hybrid

Homo sapiens

137

CCDC140

Affinity Capture-MS

Homo sapiens

138

RPL26

6154

Affinity Capture-MS

Homo sapiens

139

ZC3H3

Affinity Capture-MS

Homo sapiens

140

FHL2

2274

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

141

CCDC8

Affinity Capture-MS

Homo sapiens

142

RPS16

6217

Affinity Capture-MS

Homo sapiens

143

RPL19

6143

Affinity Capture-MS

Homo sapiens

144

Smchd1

Affinity Capture-MS

Mus musculus

145

RPL13

6137

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

146

NTMT1

28989

Two-hybrid

Homo sapiens

147

EIF1AD

84285

Two-hybrid

Homo sapiens

148

SURF6

Affinity Capture-MS

Homo sapiens

149

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

150

RBM34

Affinity Capture-MS

Homo sapiens

151

PARP1

142

Proximity Label-MS

Homo sapiens

152

HMGN4

Affinity Capture-MS

Homo sapiens

153

PDGFB

Affinity Capture-MS

Homo sapiens

154

ILF3

3609

Affinity Capture-MS

Homo sapiens

155

ALOXE3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

156

RRS1

23212

Affinity Capture-MS

Homo sapiens

157

MNDA

4332

Affinity Capture-MS

Homo sapiens

158

KDM1B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

159

USP36

Affinity Capture-MS

Homo sapiens

160

LIN28A

Affinity Capture-MS

Homo sapiens

161

DGCR8

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

162

HMGN5

79366

Affinity Capture-MS

Homo sapiens

163

KNOP1

400506

Affinity Capture-MS

Homo sapiens

164

UTP23

Affinity Capture-MS

Homo sapiens

165

ELAVL1

1994

Affinity Capture-RNA

Homo sapiens

166

CAPRIN1

4076

Affinity Capture-MS

Homo sapiens

167

H2AFB3

Affinity Capture-MS

Homo sapiens

168

SERPINA12

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

169

HIST1H1B

3009

Affinity Capture-MS

Homo sapiens

170

NEFH

4744

Affinity Capture-MS

Homo sapiens

171

TOP2A

7153

Co-fractionation

Homo sapiens

172

ESR1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

173

PRDM5

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

174

UFL1

23376

Affinity Capture-MS

Homo sapiens

175

KRR1

11103

Affinity Capture-MS

Homo sapiens

176

RBM4

5936

Affinity Capture-MS

Homo sapiens

177

NEIL1

Affinity Capture-MS

Homo sapiens

178

KDM1A

23028

Two-hybrid

Homo sapiens

179

IL17B

27190

Affinity Capture-MS

Homo sapiens

180

RPSA

3921

Affinity Capture-MS

Homo sapiens

181

GLI4

Affinity Capture-MS

Homo sapiens

182

Rrbp1

Affinity Capture-MS

Mus musculus

183

RPL8

6132

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

184

RPL28

6158

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

185

PPAN

56342

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

186

HNRNPU

3192

Affinity Capture-MS

Homo sapiens

187

ECM1

1893

Affinity Capture-MS

Homo sapiens

188

RPL36AL

6166

Affinity Capture-MS

Homo sapiens

189

RC3H1

149041

Affinity Capture-MS

Homo sapiens

190

SRSF7

6432

Affinity Capture-MS

Homo sapiens

191

PRMT1

3276

Affinity Capture-MS

Homo sapiens

192

WHSC1L1

Two-hybrid

Homo sapiens

193

RPL17

6139

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which GLYR1 is involved
No pathways found

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