Gene description for PHF14
Gene name PHD finger protein 14
Gene symbol PHF14
Other names/aliases -
Species Homo sapiens
 Database cross references - PHF14
ExoCarta ExoCarta_9678
Vesiclepedia VP_9678
Entrez Gene 9678
HGNC 22203
UniProt O94880  
 PHF14 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
 Gene ontology annotations for PHF14
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 ISS
    histone binding GO:0042393 IDA
    histone reader activity GO:0140566 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    germinal center B cell differentiation GO:0002314 ISS
    chromatin organization GO:0006325 IEA
    negative regulation of cell population proliferation GO:0008285 ISS
    mesenchymal cell proliferation GO:0010463 ISS
    lung alveolus development GO:0048286 ISS
    mesenchymal cell proliferation involved in lung development GO:0060916 ISS
    negative regulation of mesenchymal cell proliferation GO:0072201 ISS
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000584 ISS
    negative regulation of mesenchymal cell proliferation involved in lung development GO:2000791 ISS
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IEA
    chromosome GO:0005694 IEA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified PHF14 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PHF14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
3 INSIG1  
Affinity Capture-MS Homo sapiens
4 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
5 NAP1L4 4676
Affinity Capture-MS Homo sapiens
6 NUMA1 4926
Affinity Capture-MS Homo sapiens
7 APLP2 334
Co-fractionation Homo sapiens
8 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
9 ZBTB2 57621
Affinity Capture-MS Homo sapiens
10 ASF1A 25842
Proximity Label-MS Homo sapiens
11 HDAC2 3066
Affinity Capture-MS Homo sapiens
12 Ercc6l  
Affinity Capture-MS Mus musculus
13 CEP170P1  
Affinity Capture-MS Homo sapiens
14 EEF1G 1937
Co-fractionation Homo sapiens
15 TOP1 7150
Affinity Capture-MS Homo sapiens
16 RNPS1 10921
Affinity Capture-MS Homo sapiens
17 CSNK2A2 1459
Co-fractionation Homo sapiens
18 INSIG2  
Affinity Capture-MS Homo sapiens
19 MAPK1 5594
Affinity Capture-MS Homo sapiens
20 SSRP1 6749
Affinity Capture-MS Homo sapiens
21 H2AFZ 3015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 HMGN5 79366
Affinity Capture-MS Homo sapiens
24 TEX10 54881
Cross-Linking-MS (XL-MS) Homo sapiens
25 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
26 ANAPC1 64682
Co-fractionation Homo sapiens
27 GON4L  
Affinity Capture-MS Homo sapiens
28 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CHD4 1108
Affinity Capture-MS Homo sapiens
30 Fbxo21  
Affinity Capture-MS Mus musculus
31 DRG1 4733
Affinity Capture-MS Homo sapiens
32 RBBP4 5928
Affinity Capture-MS Homo sapiens
33 EIF3A 8661
Co-fractionation Homo sapiens
34 CENPA  
Proximity Label-MS Homo sapiens
35 CFDP1  
Co-fractionation Homo sapiens
36 Mta1  
Affinity Capture-MS Mus musculus
37 MIF 4282
Affinity Capture-MS Homo sapiens
38 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
39 C12orf49  
Negative Genetic Homo sapiens
40 CBX1 10951
Affinity Capture-MS Homo sapiens
41 Srp72  
Affinity Capture-MS Mus musculus
42 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
43 PRC1 9055
Affinity Capture-MS Homo sapiens
44 NLRP3  
Affinity Capture-MS Homo sapiens
45 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 RBM3 5935
Affinity Capture-MS Homo sapiens
47 AIM2  
Affinity Capture-MS Homo sapiens
48 TCF20  
Affinity Capture-MS Homo sapiens
49 PCBD2 84105
Two-hybrid Homo sapiens
50 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
51 CDK2AP1  
Affinity Capture-MS Homo sapiens
52 EIF3B 8662
Co-fractionation Homo sapiens
53 MOV10 4343
Affinity Capture-RNA Homo sapiens
54 MIER1  
Affinity Capture-MS Homo sapiens
55 TM9SF4 9777
Affinity Capture-MS Homo sapiens
56 Mllt1  
Affinity Capture-MS Mus musculus
57 KAT6A  
Affinity Capture-MS Homo sapiens
58 PARP1 142
Affinity Capture-MS Homo sapiens
59 HNRNPU 3192
Affinity Capture-MS Homo sapiens
60 MRPL39 54148
Affinity Capture-MS Homo sapiens
61 NUCKS1 64710
Affinity Capture-MS Homo sapiens
62 HMGA1 3159
Affinity Capture-MS Homo sapiens
63 HMG20A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 HIST2H2AA4 723790
Affinity Capture-MS Homo sapiens
65 H2AFY 9555
Affinity Capture-MS Homo sapiens
66 PPM1G 5496
Affinity Capture-MS Homo sapiens
67 SUPT16H 11198
Affinity Capture-MS Homo sapiens
68 PYHIN1  
Affinity Capture-MS Homo sapiens
69 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
70 DAXX  
Affinity Capture-MS Homo sapiens
71 CT45A5  
Affinity Capture-MS Homo sapiens
72 H2AFX 3014
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PHF14 is involved
No pathways found





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