Gene description for PAPD5
Gene name PAP associated domain containing 5
Gene symbol PAPD5
Other names/aliases TRF4-2
Species Homo sapiens
 Database cross references - PAPD5
ExoCarta ExoCarta_64282
Entrez Gene 64282
HGNC 30758
MIM 605540
UniProt Q8NDF8  
 PAPD5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PAPD5
Molecular Function
    metal ion binding GO:0046872 IEA
    polynucleotide adenylyltransferase activity GO:0004652 IEA
    DNA binding GO:0003677 IEA
    poly(A) RNA binding GO:0044822 IDA
    DNA-directed DNA polymerase activity GO:0003887 IEA
Biological Process
    cell division GO:0051301 IEA
    DNA biosynthetic process GO:0071897 IEA
    mRNA processing GO:0006397 IEA
    histone mRNA catabolic process GO:0071044 IMP
    mitotic nuclear division GO:0007067 IEA
    rRNA processing GO:0006364 IEA
Subcellular Localization
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 IEA
    cellular_component GO:0005575 ND
 Experiment description of studies that identified PAPD5 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PAPD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PAPD5 is involved
No pathways found





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