Gene description for CDK17
Gene name cyclin-dependent kinase 17
Gene symbol CDK17
Other names/aliases PCTAIRE2
PCTK2
Species Homo sapiens
 Database cross references - CDK17
ExoCarta ExoCarta_5128
Entrez Gene 5128
HGNC 8750
MIM 603440
UniProt Q00537  
 CDK17 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CDK17
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA
    protein kinase activity GO:0004672 TAS
Biological Process
    regulation of cell cycle GO:0051726 IEA
    protein phosphorylation GO:0006468 IEA
 Experiment description of studies that identified CDK17 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CDK17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TDRD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CDK17 is involved
No pathways found





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