Gene description for HDGFRP3
Gene name hepatoma-derived growth factor, related protein 3
Gene symbol HDGFRP3
Other names/aliases CGI-142
HDGF-2
HDGF2
HRP-3
Species Homo sapiens
 Database cross references - HDGFRP3
ExoCarta ExoCarta_50810
Vesiclepedia VP_50810
Entrez Gene 50810
UniProt Q9Y3E1  
 HDGFRP3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HDGFRP3
Molecular Function
    microtubule binding GO:0008017 ISS
    growth factor activity GO:0008083 IEA
    tubulin binding GO:0015631 ISS
Biological Process
    negative regulation of microtubule depolymerization GO:0007026 ISS
    signal transduction GO:0007165 IEA
    neuron projection development GO:0031175 ISS
    microtubule polymerization GO:0046785 ISS
Subcellular Localization
    extracellular region GO:0005576 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 ISS
 Experiment description of studies that identified HDGFRP3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HDGFRP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK17 5128
Affinity Capture-MS Homo sapiens
2 BSCL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 FAM161A  
Affinity Capture-MS Homo sapiens
4 RBM42  
Affinity Capture-MS Homo sapiens
5 PARP1 142
Affinity Capture-MS Homo sapiens
6 GRB2 2885
Affinity Capture-MS Homo sapiens
7 SLC30A6 55676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ZNF280A  
Affinity Capture-MS Homo sapiens
9 TMEM128  
Affinity Capture-MS Homo sapiens
10 BAZ2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CDKL5  
Affinity Capture-MS Homo sapiens
12 TERF2IP 54386
Two-hybrid Homo sapiens
13 CPXCR1  
Affinity Capture-MS Homo sapiens
14 BRD3 8019
Affinity Capture-MS Homo sapiens
15 NOD2 64127
Affinity Capture-MS Homo sapiens
16 SF3B2 10992
Affinity Capture-MS Homo sapiens
17 VPS37A 137492
Affinity Capture-MS Homo sapiens
18 GPANK1  
Affinity Capture-MS Homo sapiens
19 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
20 SENP8  
Affinity Capture-MS Homo sapiens
21 TRIM21 6737
Co-fractionation Homo sapiens
22 ZNF23  
Affinity Capture-MS Homo sapiens
23 ZRANB3  
Affinity Capture-MS Homo sapiens
24 DPF3  
Affinity Capture-MS Homo sapiens
25 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
26 RNF13 11342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MTERF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ZIC2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HDGFRP3 is involved
No pathways found





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