Gene description for VPS37A
Gene name vacuolar protein sorting 37 homolog A (S. cerevisiae)
Gene symbol VPS37A
Other names/aliases HCRP1
PQBP2
SPG53
Species Homo sapiens
 Database cross references - VPS37A
ExoCarta ExoCarta_137492
Vesiclepedia VP_137492
Entrez Gene 137492
HGNC 24928
MIM 609927
UniProt Q8NEZ2  
 VPS37A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VPS37A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein targeting to membrane GO:0006612 IBA
    protein targeting to vacuole GO:0006623 IBA
    macroautophagy GO:0016236 TAS
    multivesicular body assembly GO:0036258 NAS
    multivesicular body assembly GO:0036258 TAS
    viral budding via host ESCRT complex GO:0039702 TAS
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IBA
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IC
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IMP
    protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043328 NAS
    membrane fission GO:0090148 NAS
Subcellular Localization
    ESCRT I complex GO:0000813 IBA
    ESCRT I complex GO:0000813 IDA
    ESCRT I complex GO:0000813 IPI
    ESCRT I complex GO:0000813 ISS
    ESCRT I complex GO:0000813 TAS
    nucleoplasm GO:0005654 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    endosome membrane GO:0010008 NAS
    endosome membrane GO:0010008 TAS
    late endosome membrane GO:0031902 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified VPS37A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VPS37A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM42  
Two-hybrid Homo sapiens
2 Vps28 66914
Affinity Capture-MS Mus musculus
3 UBAP1 51271
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 VPS28 51160
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 FBXL6  
Proximity Label-MS Homo sapiens
6 MVB12B 89853
Affinity Capture-Western Homo sapiens
7 XPO1 7514
Affinity Capture-MS Homo sapiens
8 TSG101 7251
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
9 PHF2  
Affinity Capture-MS Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
11 ARRDC1 92714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ZFYVE16  
Affinity Capture-MS Homo sapiens
13 TRIM55  
Two-hybrid Homo sapiens
14 COPA 1314
Affinity Capture-MS Homo sapiens
15 DDX58 23586
Affinity Capture-RNA Homo sapiens
16 APP 351
Reconstituted Complex Homo sapiens
17 KDM1A 23028
Two-hybrid Homo sapiens
18 CDH1 999
Negative Genetic Homo sapiens
19 HDGFRP3 50810
Affinity Capture-MS Homo sapiens
20 S1PR1 1901
Affinity Capture-MS Homo sapiens
21 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
22 KRAS 3845
Negative Genetic Homo sapiens
23 ALG2 85365
Affinity Capture-Western Homo sapiens
24 Tsg101 22088
Affinity Capture-MS Mus musculus
25 TRIM63  
Two-hybrid Homo sapiens
26 MVB12A 93343
Affinity Capture-Western Homo sapiens
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