Gene description for DOCK6
Gene name dedicator of cytokinesis 6
Gene symbol DOCK6
Other names/aliases AOS2
ZIR1
Species Homo sapiens
 Database cross references - DOCK6
ExoCarta ExoCarta_57572
Vesiclepedia VP_57572
Entrez Gene 57572
HGNC 19189
MIM 614194
UniProt Q96HP0  
 DOCK6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DOCK6
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    protein binding GO:0005515 IPI
Biological Process
    small GTPase-mediated signal transduction GO:0007264 IEA
    regulation of Rho protein signal transduction GO:0035023 IBA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified DOCK6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DOCK6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REEP5 7905
Affinity Capture-MS Homo sapiens
2 MECP2 4204
Affinity Capture-MS Homo sapiens
3 LRCH2  
Affinity Capture-MS Homo sapiens
4 DYNC1LI1 51143
Affinity Capture-MS Homo sapiens
5 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MOB1B 92597
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
7 DOCK8 81704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 XPO1 7514
Affinity Capture-MS Homo sapiens
9 DOCK7 85440
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 Msn 17698
Affinity Capture-MS Mus musculus
11 Kifc1  
Affinity Capture-MS Mus musculus
12 Smad3  
Affinity Capture-MS Mus musculus
13 MRPS14  
Affinity Capture-MS Homo sapiens
14 Cep135  
Affinity Capture-MS Mus musculus
15 PDHA1 5160
Affinity Capture-MS Homo sapiens
16 ATG101  
Affinity Capture-MS Homo sapiens
17 UBC 7316
Reconstituted Complex Homo sapiens
18 RAB32 10981
Affinity Capture-MS Homo sapiens
19 KIF7 374654
Affinity Capture-MS Homo sapiens
20 Rock1  
Affinity Capture-MS Mus musculus
21 METTL21B  
Affinity Capture-MS Homo sapiens
22 RRP9 9136
Affinity Capture-MS Homo sapiens
23 RTN4 57142
Affinity Capture-MS Homo sapiens
24 ISM2  
Affinity Capture-MS Homo sapiens
25 RNASEH2A 10535
Affinity Capture-MS Homo sapiens
26 CUL9  
Affinity Capture-MS Homo sapiens
27 LRCH4  
Affinity Capture-MS Homo sapiens
28 RAB2A 5862
Affinity Capture-MS Homo sapiens
29 MYH6 4624
Affinity Capture-MS Homo sapiens
30 DYRK1A 1859
Affinity Capture-MS Homo sapiens
31 CLU 1191
Affinity Capture-MS Homo sapiens
32 RAB7A 7879
Proximity Label-MS Homo sapiens
33 TADA2A  
Affinity Capture-MS Homo sapiens
34 NSRP1  
Affinity Capture-MS Homo sapiens
35 HYOU1 10525
Affinity Capture-MS Homo sapiens
36 CUL7 9820
Affinity Capture-MS Homo sapiens
37 PSMD12 5718
Affinity Capture-MS Homo sapiens
38 MOB1A 55233
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
39 ZNF331  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 DLAT 1737
Affinity Capture-MS Homo sapiens
41 AGBL4  
Affinity Capture-MS Homo sapiens
42 CRLF3 51379
Affinity Capture-MS Homo sapiens
43 LRCH1 23143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SLC33A1 9197
Affinity Capture-MS Homo sapiens
45 TULP3 7289
Affinity Capture-MS Homo sapiens
46 EIF3D 8664
Affinity Capture-MS Homo sapiens
47 LRCH3 84859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 LRP8 7804
Affinity Capture-MS Homo sapiens
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