Gene description for LRCH1
Gene name leucine-rich repeats and calponin homology (CH) domain containing 1
Gene symbol LRCH1
Other names/aliases CHDC1
NP81
Species Homo sapiens
 Database cross references - LRCH1
ExoCarta ExoCarta_23143
Vesiclepedia VP_23143
Entrez Gene 23143
HGNC 20309
MIM 610368
UniProt Q9Y2L9  
 LRCH1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LRCH1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of GTPase activity GO:0034260 IDA
    cellular response to chemokine GO:1990869 IBA
    cellular response to chemokine GO:1990869 IMP
    negative regulation of T cell migration GO:2000405 IBA
    negative regulation of T cell migration GO:2000405 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IMP
 Experiment description of studies that identified LRCH1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRCH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CALML3 810
Affinity Capture-MS Homo sapiens
2 SUGT1 10910
Affinity Capture-MS Homo sapiens
3 LRRC15 131578
Affinity Capture-MS Homo sapiens
4 MECP2 4204
Affinity Capture-MS Homo sapiens
5 LRCH2  
Affinity Capture-MS Homo sapiens
6 SELENBP1 8991
Affinity Capture-MS Homo sapiens
7 LYG2  
Affinity Capture-MS Homo sapiens
8 DSG4 147409
Affinity Capture-MS Homo sapiens
9 MOB1B 92597
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
10 ABCB8 11194
Affinity Capture-MS Homo sapiens
11 KIF14 9928
Affinity Capture-MS Homo sapiens
12 DOCK8 81704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
13 XPO1 7514
Affinity Capture-MS Homo sapiens
14 DOCK7 85440
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
15 DSTYK 25778
Affinity Capture-MS Homo sapiens
16 YWHAE 7531
Affinity Capture-MS Homo sapiens
17 TMEM14B  
Two-hybrid Homo sapiens
18 YWHAZ 7534
Affinity Capture-MS Homo sapiens
19 VSIG8  
Affinity Capture-MS Homo sapiens
20 PPP1R15B  
Affinity Capture-MS Homo sapiens
21 TAP2 6891
Affinity Capture-MS Homo sapiens
22 Nfya  
Affinity Capture-MS Mus musculus
23 S100A3  
Affinity Capture-MS Homo sapiens
24 PSME1 5720
Affinity Capture-MS Homo sapiens
25 ATP2A3 489
Affinity Capture-MS Homo sapiens
26 MIF 4282
Affinity Capture-MS Homo sapiens
27 HEPHL1  
Affinity Capture-MS Homo sapiens
28 LRCH4  
Affinity Capture-MS Homo sapiens
29 CCNB1 891
Affinity Capture-MS Homo sapiens
30 MYO6 4646
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 DYRK1A 1859
Affinity Capture-MS Homo sapiens
32 NTRK1 4914
Affinity Capture-MS Homo sapiens
33 SMAD3 4088
Affinity Capture-MS Homo sapiens
34 TMEM38B  
Affinity Capture-MS Homo sapiens
35 DUSP14 11072
Affinity Capture-MS Homo sapiens
36 EPHA2 1969
Proximity Label-MS Homo sapiens
37 ZUFSP 221302
Affinity Capture-MS Homo sapiens
38 CALD1 800
Affinity Capture-MS Homo sapiens
39 CERS6  
Affinity Capture-MS Homo sapiens
40 RNF2  
Affinity Capture-MS Homo sapiens
41 MOB1A 55233
Proximity Label-MS Homo sapiens
42 TRIM29 23650
Affinity Capture-MS Homo sapiens
43 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
44 CALM3 808
Affinity Capture-MS Homo sapiens
45 DOCK6 57572
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 NOTCH1 4851
Affinity Capture-MS Homo sapiens
47 KIAA0922  
Affinity Capture-MS Homo sapiens
48 FAM26D  
Affinity Capture-MS Homo sapiens
49 TULP3 7289
Affinity Capture-MS Homo sapiens
50 LRCH3 84859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRCH1 is involved
No pathways found





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