Gene description for TAP2
Gene name transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene symbol TAP2
Other names/aliases ABC18
ABCB3
APT2
D6S217E
PSF-2
PSF2
RING11
Species Homo sapiens
 Database cross references - TAP2
ExoCarta ExoCarta_6891
Vesiclepedia VP_6891
Entrez Gene 6891
HGNC 44
MIM 170261
UniProt Q03519  
 TAP2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TAP2
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP binding GO:0005524 IMP
    ABC-type peptide antigen transporter activity GO:0015433 IDA
    ABC-type peptide antigen transporter activity GO:0015433 IGI
    ABC-type peptide antigen transporter activity GO:0015433 IMP
    ABC-type peptide transporter activity GO:0015440 IBA
    ATP hydrolysis activity GO:0016887 IEA
    MHC class Ib protein binding GO:0023029 IPI
    peptide antigen binding GO:0042605 IDA
    metal ion binding GO:0046872 IEA
    TAP1 binding GO:0046978 IPI
    tapasin binding GO:0046980 ISS
    peptide transmembrane transporter activity GO:1904680 IGI
Biological Process
    T cell mediated cytotoxicity GO:0001913 IEA
    positive regulation of T cell mediated cytotoxicity GO:0001916 IEA
    response to molecule of bacterial origin GO:0002237 IEA
    antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IEA
    antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent GO:0002485 IEA
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent GO:0002489 IMP
    protein transport GO:0015031 IEA
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IDA
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IMP
    cytosol to endoplasmic reticulum transport GO:0046967 IMP
    peptide antigen transport GO:0046968 IDA
    peptide antigen transport GO:0046968 IMP
    transmembrane transport GO:0055085 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    nuclear speck GO:0016607 IDA
    phagocytic vesicle membrane GO:0030670 TAS
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 TAS
    MHC class I peptide loading complex GO:0042824 IBA
    MHC class I peptide loading complex GO:0042824 IDA
    TAP complex GO:0042825 IDA
 Experiment description of studies that identified TAP2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TAP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 NKAIN1  
Affinity Capture-MS Homo sapiens
3 CANX 821
Affinity Capture-MS Homo sapiens
4 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SLC17A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KCNMB3  
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 FMNL1 752
Affinity Capture-MS Homo sapiens
9 RAMP2  
Affinity Capture-MS Homo sapiens
10 SLC30A2  
Affinity Capture-MS Homo sapiens
11 CD3D 915
Affinity Capture-MS Homo sapiens
12 VAPB 9217
Affinity Capture-MS Homo sapiens
13 RXFP1  
Affinity Capture-MS Homo sapiens
14 SLC22A2 6582
Affinity Capture-MS Homo sapiens
15 ATL3 25923
Affinity Capture-MS Homo sapiens
16 HLA-E 3133
Affinity Capture-Western Homo sapiens
17 LRRC55  
Affinity Capture-MS Homo sapiens
18 FGD1  
Affinity Capture-MS Homo sapiens
19 B2M 567
Affinity Capture-Western Homo sapiens
20 MFSD4  
Affinity Capture-MS Homo sapiens
21 TCIRG1 10312
Affinity Capture-MS Homo sapiens
22 HLA-A 3105
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 B3GNT3 10331
Affinity Capture-MS Homo sapiens
24 CHRNA1  
Affinity Capture-MS Homo sapiens
25 EFNA5  
Affinity Capture-MS Homo sapiens
26 Atp2a2 11938
Affinity Capture-MS Mus musculus
27 GPR12  
Affinity Capture-MS Homo sapiens
28 TYROBP  
Affinity Capture-MS Homo sapiens
29 Timeless  
Affinity Capture-MS Mus musculus
30 CHRNA7  
Affinity Capture-MS Homo sapiens
31 HLA-G 3135
Affinity Capture-Western Homo sapiens
32 KLRD1  
Affinity Capture-MS Homo sapiens
33 RBM18  
Two-hybrid Homo sapiens
34 KLRB1  
Affinity Capture-MS Homo sapiens
35 ZNF281  
Affinity Capture-MS Homo sapiens
36 DDX58 23586
Affinity Capture-RNA Homo sapiens
37 SCAP  
Affinity Capture-MS Homo sapiens
38 PSMB8 5696
Two-hybrid Homo sapiens
39 APP 351
Reconstituted Complex Homo sapiens
40 CYP19A1  
Affinity Capture-MS Homo sapiens
41 Cdc16  
Affinity Capture-MS Mus musculus
42 APEX1 328
Affinity Capture-RNA Homo sapiens
43 TMEM25  
Affinity Capture-MS Homo sapiens
44 MASTL  
Affinity Capture-MS Homo sapiens
45 Tox4  
Affinity Capture-MS Mus musculus
46 TAPBP 6892
Reconstituted Complex Homo sapiens
47 PSMG3 84262
Two-hybrid Homo sapiens
48 C3orf52  
Affinity Capture-MS Homo sapiens
49 CCDC107  
Affinity Capture-MS Homo sapiens
50 LRCH1 23143
Affinity Capture-MS Homo sapiens
51 CKAP5 9793
Affinity Capture-MS Homo sapiens
52 CMTM5  
Affinity Capture-MS Homo sapiens
53 HLA-B 3106
Affinity Capture-MS Homo sapiens
54 GPR182  
Affinity Capture-MS Homo sapiens
55 Zbtb48  
Affinity Capture-MS Mus musculus
56 PTCHD3  
Affinity Capture-MS Homo sapiens
57 MARCH4  
Affinity Capture-MS Homo sapiens
58 KCNA2  
Affinity Capture-MS Homo sapiens
59 PML 5371
Affinity Capture-MS Homo sapiens
60 TAP1 6890
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 GRIN2A  
Affinity Capture-MS Homo sapiens
62 RNF185  
Affinity Capture-MS Homo sapiens
63 PIGH  
Affinity Capture-MS Homo sapiens
64 SCNN1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 TMCO3 55002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 PTCH2  
Affinity Capture-MS Homo sapiens
67 HLA-C 3107
Affinity Capture-Western Homo sapiens
68 EDAR  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here