Gene description for TCIRG1
Gene name T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
Gene symbol TCIRG1
Other names/aliases ATP6N1C
ATP6V0A3
Atp6i
OC-116kDa
OC116
OPTB1
Stv1
TIRC7
Vph1
a3
Species Homo sapiens
 Database cross references - TCIRG1
ExoCarta ExoCarta_10312
Entrez Gene 10312
HGNC 11647
MIM 604592
UniProt Q13488  
 TCIRG1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TCIRG1
Molecular Function
    transporter activity GO:0005215 TAS
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IBA
    ATPase binding GO:0051117 IBA
Biological Process
    phagosome maturation GO:0090382 TAS
    positive regulation of cell proliferation GO:0008284 TAS
    transmembrane transport GO:0055085 TAS
    cellular defense response GO:0006968 TAS
    cellular iron ion homeostasis GO:0006879 TAS
    ATP hydrolysis coupled proton transport GO:0015991 IEA
    proton transport GO:0015992 TAS
    ATP synthesis coupled proton transport GO:0015986 IBA
    insulin receptor signaling pathway GO:0008286 TAS
    vacuolar proton-transporting V-type ATPase complex assembly GO:0070072 IBA
    transferrin transport GO:0033572 TAS
    ion transmembrane transport GO:0034220 TAS
    vacuolar acidification GO:0007035 IBA
    interaction with host GO:0051701 TAS
Subcellular Localization
    vacuolar proton-transporting V-type ATPase complex GO:0016471 IBA
    apical plasma membrane GO:0016324 IDA
    endosome membrane GO:0010008 TAS
    mitochondrion GO:0005739 IEA
    vacuolar proton-transporting V-type ATPase, V0 domain GO:0000220 IEA
    integral component of plasma membrane GO:0005887 TAS
    lysosomal membrane GO:0005765 IDA
    plasma membrane GO:0005886 TAS
    phagocytic vesicle membrane GO:0030670 TAS
 Experiment description of studies that identified TCIRG1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TCIRG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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