Gene description for AP3D1
Gene name adaptor-related protein complex 3, delta 1 subunit
Gene symbol AP3D1
Other names/aliases ADTD
hBLVR
Species Homo sapiens
 Database cross references - AP3D1
ExoCarta ExoCarta_8943
Entrez Gene 8943
HGNC 568
MIM 607246
UniProt O14617  
 AP3D1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for AP3D1
Molecular Function
    transporter activity GO:0005215 TAS
Biological Process
    anterograde synaptic vesicle transport GO:0048490 ISS
    synaptic vesicle membrane organization GO:0048499 IEA
    positive regulation of NK T cell differentiation GO:0051138 IEA
    melanosome organization GO:0032438 IC
    protein localization to organelle GO:0033365 IEA
    antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 IEA
    regulation of sequestering of zinc ion GO:0061088 IMP
    intracellular protein transport GO:0006886 IEA
    eye pigment biosynthetic process GO:0006726 TAS
    protein localization to membrane GO:0072657 IMP
    anterograde axon cargo transport GO:0008089 ISS
    endosome to melanosome transport GO:0035646 IMP
Subcellular Localization
    membrane coat GO:0030117 IEA
    nucleoplasm GO:0005654 IDA
    terminal bouton GO:0043195 IEA
    Golgi apparatus GO:0005794 TAS
    lysosomal membrane GO:0005765 IDA
    endosome membrane GO:0010008 IDA
    Golgi membrane GO:0000139 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified AP3D1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AP3D1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VAMP7 6845
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 ARF1 375
Affinity Capture-MS Homo sapiens
3 ARF6 382
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AP3D1 is involved
No pathways found





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