Gene description for AP3B2
Gene name adaptor-related protein complex 3, beta 2 subunit
Gene symbol AP3B2
Other names/aliases NAPTB
Species Homo sapiens
 Database cross references - AP3B2
ExoCarta ExoCarta_8120
Vesiclepedia VP_8120
Entrez Gene 8120
HGNC 567
MIM 602166
UniProt Q13367  
 AP3B2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for AP3B2
Biological Process
    intracellular protein transport GO:0006886 IEA
    anterograde axonal transport GO:0008089 ISS
    synaptic vesicle coating GO:0016183 NAS
    vesicle-mediated transport GO:0016192 IBA
    clathrin-coated vesicle cargo loading, AP-3-mediated GO:0035654 NAS
    synaptic vesicle recycling GO:0036465 NAS
    intracellular transport GO:0046907 NAS
    anterograde synaptic vesicle transport GO:0048490 IBA
    anterograde synaptic vesicle transport GO:0048490 ISS
Subcellular Localization
    early endosome GO:0005769 NAS
    Golgi apparatus GO:0005794 IEA
    AP-3 adaptor complex GO:0030123 NAS
    clathrin-coated vesicle membrane GO:0030665 IEA
    intracellular vesicle GO:0097708 TAS
    presynapse GO:0098793 IEA
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified AP3B2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AP3B2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP3S1 1176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 GPM6A 2823
Affinity Capture-MS Homo sapiens
4 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 HADHB 3032
Co-fractionation Homo sapiens
7 KIF14 9928
Affinity Capture-MS Homo sapiens
8 ATG9A 79065
Proximity Label-MS Homo sapiens
9 EPB41L3 23136
Affinity Capture-MS Homo sapiens
10 AP3M1 26985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CUL5 8065
Affinity Capture-MS Homo sapiens
12 RUFY1 80230
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
13 PLD1 5337
Affinity Capture-MS Homo sapiens
14 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EDA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SEC62 7095
Affinity Capture-MS Homo sapiens
17 NTRK1 4914
Affinity Capture-MS Homo sapiens
18 CREB3L3  
Affinity Capture-MS Homo sapiens
19 NFKBIL1  
Affinity Capture-MS Homo sapiens
20 CLTC 1213
Reconstituted Complex Homo sapiens
21 AP3B1 8546
Cross-Linking-MS (XL-MS) Homo sapiens
22 AP3D1 8943
Affinity Capture-Western Homo sapiens
23 SYT2  
Affinity Capture-MS Homo sapiens
24 DAXX  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AP3B2 is involved
No pathways found





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