Gene description for SLC22A2
Gene name solute carrier family 22 (organic cation transporter), member 2
Gene symbol SLC22A2
Other names/aliases OCT2
Species Homo sapiens
 Database cross references - SLC22A2
ExoCarta ExoCarta_6582
Entrez Gene 6582
HGNC 10966
MIM 602608
UniProt O15244  
 SLC22A2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Urine 19056867    
 Gene ontology annotations for SLC22A2
Molecular Function
    quaternary ammonium group transmembrane transporter activity GO:0015651 IEA
    choline transmembrane transporter activity GO:0015220 IEA
    steroid binding GO:0005496 IEA
    organic cation transmembrane transporter activity GO:0015101 IDA
Biological Process
    synaptic transmission GO:0007268 TAS
    histamine transport GO:0051608 IEA
    ion transmembrane transport GO:0034220 IEA
    transmembrane transport GO:0055085 TAS
    body fluid secretion GO:0007589 TAS
    drug transmembrane transport GO:0006855 TAS
    neurotransmitter biosynthetic process GO:0042136 TAS
    choline transport GO:0015871 IEA
    neurotransmitter secretion GO:0007269 TAS
    quaternary ammonium group transport GO:0015697 IEA
    small molecule metabolic process GO:0044281 TAS
    organic cation transport GO:0015695 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    basolateral plasma membrane GO:0016323 IEA
    membrane GO:0016020 TAS
    integral component of plasma membrane GO:0005887 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLC22A2 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POU2AF1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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