Gene description for SLC22A2
Gene name solute carrier family 22 (organic cation transporter), member 2
Gene symbol SLC22A2
Other names/aliases OCT2
Species Homo sapiens
 Database cross references - SLC22A2
ExoCarta ExoCarta_6582
Vesiclepedia VP_6582
Entrez Gene 6582
HGNC 10966
MIM 602608
UniProt O15244  
 SLC22A2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Urine 19056867    
 Gene ontology annotations for SLC22A2
Molecular Function
    amine transmembrane transporter activity GO:0005275 IDA
    acetylcholine transmembrane transporter activity GO:0005277 IDA
    neurotransmitter transmembrane transporter activity GO:0005326 IDA
    neurotransmitter transmembrane transporter activity GO:0005326 TAS
    monoamine transmembrane transporter activity GO:0008504 IDA
    organic anion transmembrane transporter activity GO:0008514 IDA
    organic cation transmembrane transporter activity GO:0015101 EXP
    organic cation transmembrane transporter activity GO:0015101 IBA
    organic cation transmembrane transporter activity GO:0015101 IDA
    organic cation transmembrane transporter activity GO:0015101 IMP
    organic cation transmembrane transporter activity GO:0015101 TAS
    prostaglandin transmembrane transporter activity GO:0015132 IDA
    L-amino acid transmembrane transporter activity GO:0015179 IMP
    pyrimidine nucleoside transmembrane transporter activity GO:0015214 IMP
    choline transmembrane transporter activity GO:0015220 IDA
    thiamine transmembrane transporter activity GO:0015234 IDA
    putrescine transmembrane transporter activity GO:0015489 IDA
    efflux transmembrane transporter activity GO:0015562 IDA
    spermidine transmembrane transporter activity GO:0015606 ISS
    quaternary ammonium group transmembrane transporter activity GO:0015651 IDA
    toxin transmembrane transporter activity GO:0019534 IDA
    toxin transmembrane transporter activity GO:0019534 IMP
    toxin transmembrane transporter activity GO:0019534 ISS
    xenobiotic transmembrane transporter activity GO:0042910 IDA
    xenobiotic transmembrane transporter activity GO:0042910 IMP
    L-arginine transmembrane transporter activity GO:0061459 IMP
Biological Process
    monoatomic cation transport GO:0006812 IEA
    neurotransmitter transport GO:0006836 IDA
    neurotransmitter transport GO:0006836 TAS
    serotonin transport GO:0006837 IDA
    body fluid secretion GO:0007589 TAS
    organic cation transport GO:0015695 IBA
    organic cation transport GO:0015695 IDA
    organic cation transport GO:0015695 IDA
    organic cation transport GO:0015695 IMP
    quaternary ammonium group transport GO:0015697 IEA
    prostaglandin transport GO:0015732 IDA
    amine transport GO:0015837 IDA
    putrescine transport GO:0015847 IDA
    spermidine transport GO:0015848 ISS
    acetylcholine transport GO:0015870 IDA
    choline transport GO:0015871 IDA
    dopamine transport GO:0015872 IDA
    dopamine transport GO:0015872 ISS
    norepinephrine transport GO:0015874 IDA
    xenobiotic transport GO:0042908 IDA
    xenobiotic transport GO:0042908 IMP
    xenobiotic transport GO:0042908 ISS
    epinephrine transport GO:0048241 IDA
    epinephrine transport GO:0048241 ISS
    histamine transport GO:0051608 IDA
    serotonin uptake GO:0051610 IDA
    histamine uptake GO:0051615 IDA
    norepinephrine uptake GO:0051620 IDA
    norepinephrine uptake GO:0051620 TAS
    thiamine transmembrane transport GO:0071934 IDA
    purine-containing compound transmembrane transport GO:0072530 TAS
    amino acid import across plasma membrane GO:0089718 IMP
    dopamine uptake GO:0090494 IDA
    L-arginine import across plasma membrane GO:0097638 IMP
    export across plasma membrane GO:0140115 IDA
    transport across blood-brain barrier GO:0150104 NAS
    L-alpha-amino acid transmembrane transport GO:1902475 IMP
    spermidine transmembrane transport GO:1903711 IEA
    L-arginine transmembrane transport GO:1903826 IEA
    cellular detoxification GO:1990748 IDA
    cellular detoxification GO:1990748 IMP
    xenobiotic transport across blood-brain barrier GO:1990962 NAS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basal plasma membrane GO:0009925 IDA
    membrane GO:0016020 TAS
    basolateral plasma membrane GO:0016323 ISS
    apical plasma membrane GO:0016324 IDA
    extracellular exosome GO:0070062 HDA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified SLC22A2 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLVCR1 28982
Affinity Capture-MS Homo sapiens
2 SLC29A1 2030
Affinity Capture-MS Homo sapiens
3 ARV1  
Affinity Capture-MS Homo sapiens
4 SLC25A24 29957
Affinity Capture-MS Homo sapiens
5 MBOAT2  
Affinity Capture-MS Homo sapiens
6 ABCB8 11194
Affinity Capture-MS Homo sapiens
7 SLC26A2 1836
Affinity Capture-MS Homo sapiens
8 SLC15A4 121260
Affinity Capture-MS Homo sapiens
9 TMEM63B 55362
Affinity Capture-MS Homo sapiens
10 NEK6 10783
Affinity Capture-MS Homo sapiens
11 DDX19B 11269
Affinity Capture-MS Homo sapiens
12 SLC20A2 6575
Affinity Capture-MS Homo sapiens
13 PDK1 5163
Affinity Capture-MS Homo sapiens
14 HYAL3  
Two-hybrid Homo sapiens
15 CNNM1  
Affinity Capture-MS Homo sapiens
16 ATP8B2 57198
Affinity Capture-MS Homo sapiens
17 LSM4 25804
Two-hybrid Homo sapiens
18 GP1BB 2812
Affinity Capture-MS Homo sapiens
19 HIP1R 9026
Affinity Capture-MS Homo sapiens
20 FADS1 3992
Affinity Capture-MS Homo sapiens
21 STARD3 10948
Affinity Capture-MS Homo sapiens
22 TAP2 6891
Affinity Capture-MS Homo sapiens
23 CDYL 9425
Affinity Capture-MS Homo sapiens
24 CHPT1  
Affinity Capture-MS Homo sapiens
25 MCU 90550
Affinity Capture-MS Homo sapiens
26 EXT2 2132
Two-hybrid Homo sapiens
27 ETV5  
Two-hybrid Homo sapiens
28 APOOL 139322
Affinity Capture-MS Homo sapiens
29 KCNJ8  
Affinity Capture-MS Homo sapiens
30 SLC9A1 6548
Affinity Capture-MS Homo sapiens
31 SUMO2 6613
Two-hybrid Homo sapiens
32 NR2F2  
Affinity Capture-MS Homo sapiens
33 SMPD2 6610
Affinity Capture-MS Homo sapiens
34 PRC1 9055
Affinity Capture-MS Homo sapiens
35 AGO3  
Two-hybrid Homo sapiens
36 ABCB10 23456
Affinity Capture-MS Homo sapiens
37 CST9L  
Two-hybrid Homo sapiens
38 SLC47A1  
Affinity Capture-MS Homo sapiens
39 ABHD17B 51104
Affinity Capture-MS Homo sapiens
40 ATP11C 286410
Affinity Capture-MS Homo sapiens
41 GLRB  
Affinity Capture-MS Homo sapiens
42 ACSL4 2182
Affinity Capture-MS Homo sapiens
43 GTF2B 2959
Two-hybrid Homo sapiens
View the network image/svg+xml



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