Gene description for FLVCR1
Gene name feline leukemia virus subgroup C cellular receptor 1
Gene symbol FLVCR1
Other names/aliases AXPC1
FLVCR
MFSD7B
PCA
PCARP
Species Homo sapiens
 Database cross references - FLVCR1
ExoCarta ExoCarta_28982
Vesiclepedia VP_28982
Entrez Gene 28982
HGNC 24682
MIM 609144
UniProt Q9Y5Y0  
 FLVCR1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FLVCR1
Molecular Function
    protein binding GO:0005515 IPI
    choline transmembrane transporter activity GO:0015220 IDA
    heme transmembrane transporter activity GO:0015232 IBA
    heme transmembrane transporter activity GO:0015232 IDA
    heme transmembrane transporter activity GO:0015232 IMP
    heme transmembrane transporter activity GO:0015232 TAS
    heme binding GO:0020037 IBA
    ethanolamine transmembrane transporter activity GO:0034228 IDA
Biological Process
    blood vessel development GO:0001568 IEA
    in utero embryonic development GO:0001701 IEA
    heme biosynthetic process GO:0006783 TAS
    mitochondrial transport GO:0006839 IBA
    mitochondrial transport GO:0006839 IDA
    intracellular iron ion homeostasis GO:0006879 TAS
    phospholipid biosynthetic process GO:0008654 IDA
    choline transport GO:0015871 IDA
    heme transport GO:0015886 IMP
    erythrocyte differentiation GO:0030218 IBA
    erythrocyte differentiation GO:0030218 IDA
    ethanolamine transport GO:0034229 IEA
    multicellular organism growth GO:0035264 IEA
    embryonic digit morphogenesis GO:0042733 IEA
    erythrocyte maturation GO:0043249 IEA
    regulation of organ growth GO:0046620 IEA
    spleen development GO:0048536 IEA
    embryonic skeletal system morphogenesis GO:0048704 IEA
    transmembrane transport GO:0055085 IEA
    head morphogenesis GO:0060323 IEA
    heme export GO:0097037 IBA
    heme export GO:0097037 IMP
Subcellular Localization
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IBA
 Experiment description of studies that identified FLVCR1 in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
5
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FLVCR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTGIR  
Affinity Capture-MS Homo sapiens
2 CRELD1 78987
Affinity Capture-MS Homo sapiens
3 RAB5C 5878
Proximity Label-MS Homo sapiens
4 NT5E 4907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 SLC17A2  
Affinity Capture-MS Homo sapiens
7 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 VIPR2  
Affinity Capture-MS Homo sapiens
10 CYB5B 80777
Affinity Capture-MS Homo sapiens
11 TMEM9 252839
Affinity Capture-MS Homo sapiens
12 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MCAM 4162
Proximity Label-MS Homo sapiens
14 SLC22A2 6582
Affinity Capture-MS Homo sapiens
15 TP53 7157
Affinity Capture-MS Homo sapiens
16 MARCKS 4082
Proximity Label-MS Homo sapiens
17 LAMP3  
Proximity Label-MS Homo sapiens
18 MICA 100507436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PANX1 24145
Proximity Label-MS Homo sapiens
20 GJA1 2697
Proximity Label-MS Homo sapiens
21 C7orf34  
Affinity Capture-MS Homo sapiens
22 RAB5A 5868
Proximity Label-MS Homo sapiens
23 LAMP1 3916
Proximity Label-MS Homo sapiens
24 RAB35 11021
Proximity Label-MS Homo sapiens
25 IL2RG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 OPALIN  
Affinity Capture-MS Homo sapiens
27 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 BSCL2  
Affinity Capture-MS Homo sapiens
29 LMAN1 3998
Proximity Label-MS Homo sapiens
30 TMEM9B 56674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 LAMP2 3920
Proximity Label-MS Homo sapiens
32 ARF6 382
Proximity Label-MS Homo sapiens
33 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 KEL  
Affinity Capture-MS Homo sapiens
35 TEX29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ERGIC1 57222
Proximity Label-MS Homo sapiens
37 SLC22A16 85413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SLC7A8 23428
Affinity Capture-MS Homo sapiens
39 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 LYN 4067
Proximity Label-MS Homo sapiens
41 KIAA1467 57613
Affinity Capture-MS Homo sapiens
42 RAB4A 5867
Proximity Label-MS Homo sapiens
43 CD27  
Affinity Capture-MS Homo sapiens
44 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DNAJC5 80331
Proximity Label-MS Homo sapiens
46 B3GAT1  
Proximity Label-MS Homo sapiens
47 RAB2A 5862
Proximity Label-MS Homo sapiens
48 SLC20A1 6574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 OSTM1 28962
Affinity Capture-MS Homo sapiens
50 DIRAS3  
Proximity Label-MS Homo sapiens
51 ATP2A1 487
Proximity Label-MS Homo sapiens
52 CMTM5  
Affinity Capture-MS Homo sapiens
53 S1PR4  
Affinity Capture-MS Homo sapiens
54 TNFRSF10C  
Affinity Capture-MS Homo sapiens
55 GINM1 116254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 NHLRC3 387921
Affinity Capture-MS Homo sapiens
57 EPHA2 1969
Proximity Label-MS Homo sapiens
58 VAMP5 10791
Affinity Capture-MS Homo sapiens
59 PTH2R  
Affinity Capture-MS Homo sapiens
60 LAMTOR1 55004
Proximity Label-MS Homo sapiens
61 KRAS 3845
Proximity Label-MS Homo sapiens
62 UNC5CL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 RHOB 388
Proximity Label-MS Homo sapiens
64 KIR2DL1  
Affinity Capture-MS Homo sapiens
65 GPC1 2817
Affinity Capture-MS Homo sapiens
66 C11orf52 91894
Proximity Label-MS Homo sapiens
67 XKRX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CAV1 857
Proximity Label-MS Homo sapiens
69 CTDSPL 10217
Proximity Label-MS Homo sapiens
70 SLC2A9  
Affinity Capture-MS Homo sapiens
71 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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