Gene description for ABCB10
Gene name ATP-binding cassette, sub-family B (MDR/TAP), member 10
Gene symbol ABCB10
Other names/aliases EST20237
M-ABC2
MTABC2
Species Homo sapiens
 Database cross references - ABCB10
ExoCarta ExoCarta_23456
Vesiclepedia VP_23456
Entrez Gene 23456
HGNC 41
MIM 605454
UniProt Q9NRK6  
 ABCB10 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ABCB10
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IDA
    protein homodimerization activity GO:0042803 IDA
    ABC-type transporter activity GO:0140359 IEA
Biological Process
    heme biosynthetic process GO:0006783 ISS
    mitochondrial transport GO:0006839 NAS
    mitochondrial unfolded protein response GO:0034514 IMP
    positive regulation of erythrocyte differentiation GO:0045648 ISS
    positive regulation of hemoglobin biosynthetic process GO:0046985 IMP
    erythrocyte development GO:0048821 IMP
    transmembrane transport GO:0055085 IEA
    positive regulation of heme biosynthetic process GO:0070455 ISS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial membrane GO:0031966 IDA
 Experiment description of studies that identified ABCB10 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABCB10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRG1 3084
Affinity Capture-MS Homo sapiens
2 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RAMP3  
Affinity Capture-MS Homo sapiens
4 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CS 1431
Proximity Label-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 SPRTN  
Affinity Capture-MS Homo sapiens
8 KCNA2  
Affinity Capture-MS Homo sapiens
9 MEX3A  
Affinity Capture-RNA Homo sapiens
10 CTAGE5 4253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TTYH1  
Affinity Capture-MS Homo sapiens
12 SNX4 8723
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 RNF170 81790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CLPP 8192
Proximity Label-MS Homo sapiens
17 APOO 79135
Proximity Label-MS Homo sapiens
18 LRRC55  
Affinity Capture-MS Homo sapiens
19 SLC24A5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 KCNK1  
Affinity Capture-MS Homo sapiens
21 IL9R  
Affinity Capture-MS Homo sapiens
22 SGSM1  
Affinity Capture-MS Homo sapiens
23 PDHA1 5160
Proximity Label-MS Homo sapiens
24 DNAJA3 9093
Proximity Label-MS Homo sapiens
25 C9orf78 51759
Affinity Capture-MS Homo sapiens
26 LAMTOR2 28956
Co-fractionation Homo sapiens
27 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
28 UQCR10 29796
Affinity Capture-MS Homo sapiens
29 PARK2  
Affinity Capture-MS Homo sapiens
30 CEACAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 TNFSF18 8995
Affinity Capture-MS Homo sapiens
32 EIF2B5 8893
Affinity Capture-MS Homo sapiens
33 PDE2A  
Affinity Capture-MS Homo sapiens
34 TSPAN2 10100
Affinity Capture-MS Homo sapiens
35 BAK1 578
Co-fractionation Homo sapiens
36 SAAL1 113174
Affinity Capture-MS Homo sapiens
37 ECSIT 51295
Co-fractionation Homo sapiens
38 NDUFA2 4695
Co-fractionation Homo sapiens
39 AARS2  
Proximity Label-MS Homo sapiens
40 HLA-DPA1  
Affinity Capture-MS Homo sapiens
41 PCDHGC4  
Affinity Capture-MS Homo sapiens
42 SLC22A2 6582
Affinity Capture-MS Homo sapiens
43 SDC4 6385
Affinity Capture-MS Homo sapiens
44 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 SERBP1 26135
Affinity Capture-MS Homo sapiens
46 LGR4 55366
Affinity Capture-MS Homo sapiens
47 NDUFB11 54539
Co-fractionation Homo sapiens
48 FTL 2512
Affinity Capture-MS Homo sapiens
49 SYCE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 UPK1A 11045
Affinity Capture-MS Homo sapiens
51 KCNC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 RPA3 6119
Proximity Label-MS Homo sapiens
53 C3orf52  
Affinity Capture-MS Homo sapiens
54 KCNA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PIPSL 266971
Affinity Capture-MS Homo sapiens
56 EDAR  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ABCB10 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport TAS Reactome
Mitochondrial ABC transporters TAS Reactome
Transport of small molecules TAS Reactome





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