Gene description for RNF170
Gene name ring finger protein 170
Gene symbol RNF170
Other names/aliases ADSA
SNAX1
Species Homo sapiens
 Database cross references - RNF170
ExoCarta ExoCarta_81790
Vesiclepedia VP_81790
Entrez Gene 81790
HGNC 25358
MIM 614649
UniProt Q96K19  
 RNF170 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RNF170
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IEA
Biological Process
    adult walking behavior GO:0007628 IEA
    response to temperature stimulus GO:0009266 IEA
    gene expression GO:0010467 IEA
    response to activity GO:0014823 IEA
    toll-like receptor 3 signaling pathway GO:0034138 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    innate immune response GO:0045087 IEA
    protein K48-linked ubiquitination GO:0070936 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified RNF170 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RNF170
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATAD1 84896
Affinity Capture-MS Homo sapiens
2 PSMA6 5687
Two-hybrid Homo sapiens
3 PRICKLE3  
Affinity Capture-MS Homo sapiens
4 GABBR2  
Affinity Capture-MS Homo sapiens
5 PPAPDC2  
Two-hybrid Homo sapiens
6 UPK2 7379
Two-hybrid Homo sapiens
7 Kif2c 73804
Affinity Capture-MS Mus musculus
8 RDH14 57665
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TMBIM6 7009
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TMX3 54495
Affinity Capture-MS Homo sapiens
11 Cdc23  
Affinity Capture-MS Mus musculus
12 GPR17 2840
Affinity Capture-MS Homo sapiens
13 ST7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RNF185  
Affinity Capture-MS Homo sapiens
15 RNF170 81790
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
16 ATP13A2  
Affinity Capture-MS Homo sapiens
17 ERLIN1 10613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 UBE2L3 7332
Reconstituted Complex Homo sapiens
19 PON2 5445
Affinity Capture-MS Homo sapiens
20 AMFR 267
Affinity Capture-MS Homo sapiens
21 TMUB1  
Affinity Capture-MS Homo sapiens
22 TYW1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 GCGR  
Affinity Capture-MS Homo sapiens
24 ERLIN2 11160
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PDE3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ITPR3 3710
Affinity Capture-MS Homo sapiens
27 FXYD6-FXYD2  
Two-hybrid Homo sapiens
28 Fbxo21  
Affinity Capture-MS Mus musculus
29 C6orf120  
Affinity Capture-MS Homo sapiens
30 S100A9 6280
Affinity Capture-MS Homo sapiens
31 HSD17B12 51144
Affinity Capture-MS Homo sapiens
32 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 STARD3 10948
Two-hybrid Homo sapiens
34 SNAP47 116841
Two-hybrid Homo sapiens
35 SLC35B2 347734
Two-hybrid Homo sapiens
36 SGTB  
Two-hybrid Homo sapiens
37 UBE2D2 7322
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
38 IDH2 3418
Affinity Capture-MS Homo sapiens
39 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CHMP4B 128866
Affinity Capture-MS Homo sapiens
41 SREBF2 6721
Affinity Capture-MS Homo sapiens
42 PARD6B 84612
Affinity Capture-MS Homo sapiens
43 MYH9 4627
Affinity Capture-MS Homo sapiens
44 TMCO1 54499
Affinity Capture-MS Homo sapiens
45 DUSP3 1845
Affinity Capture-MS Homo sapiens
46 TMEM109 79073
Two-hybrid Homo sapiens
47 TMEM97 27346
Two-hybrid Homo sapiens
48 ASPHD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ITPR1 3708
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 TM9SF4 9777
Affinity Capture-MS Homo sapiens
51 COPS2 9318
Affinity Capture-MS Homo sapiens
52 SGTA 6449
Two-hybrid Homo sapiens
53 SERBP1 26135
Affinity Capture-MS Homo sapiens
54 CCR6  
Affinity Capture-MS Homo sapiens
55 RAB4B 53916
Affinity Capture-MS Homo sapiens
56 DNAJC30  
Two-hybrid Homo sapiens
57 ABCB10 23456
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 Clspn  
Affinity Capture-MS Mus musculus
59 UGGT1 56886
Affinity Capture-MS Homo sapiens
60 UBE2U  
Two-hybrid Homo sapiens
61 PTPLA  
Two-hybrid Homo sapiens
62 P2RY12 64805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RNF170 is involved
No pathways found





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