Gene description for Kif2c
Gene name kinesin family member 2C
Gene symbol Kif2c
Other names/aliases 4930402F02Rik
ESTM5
Knsl6
MCAK
X83316
Species Mus musculus
 Database cross references - Kif2c
ExoCarta ExoCarta_73804
Vesiclepedia VP_73804
Entrez Gene 73804
UniProt Q922S8  
 Kif2c identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Kif2c
Molecular Function
    microtubule motor activity GO:0003777 IBA
    microtubule motor activity GO:0003777 IEA
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IBA
    ATP hydrolysis activity GO:0016887 IBA
    microtubule plus-end binding GO:0051010 ISO
    microtubule plus-end binding GO:0051010 ISS
Biological Process
    microtubule-based movement GO:0007018 IBA
    microtubule-based movement GO:0007018 IEA
    microtubule depolymerization GO:0007019 IEA
    microtubule depolymerization GO:0007019 ISO
    mitotic metaphase chromosome alignment GO:0007080 ISO
    mitotic metaphase chromosome alignment GO:0007080 ISS
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 IEA
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 ISO
    cell division GO:0051301 IEA
    metaphase chromosome alignment GO:0051310 ISO
    metaphase chromosome alignment GO:0051310 ISS
    attachment of mitotic spindle microtubules to kinetochore GO:0051315 ISO
    attachment of mitotic spindle microtubules to kinetochore GO:0051315 ISS
    regulation of chromosome segregation GO:0051983 IEA
    regulation of chromosome segregation GO:0051983 ISO
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IDA
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IMP
    postsynaptic cytoskeleton organization GO:0099188 IDA
    postsynaptic cytoskeleton organization GO:0099188 IMP
Subcellular Localization
    chromosome, centromeric region GO:0000775 IDA
    chromosome, centromeric region GO:0000775 ISO
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISS
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IBA
    spindle GO:0005819 IBA
    kinesin complex GO:0005871 IBA
    microtubule GO:0005874 IBA
    cytoplasmic microtubule GO:0005881 ISS
    microtubule cytoskeleton GO:0015630 ISO
    microtubule plus-end GO:0035371 ISO
    microtubule plus-end GO:0035371 ISS
    presynapse GO:0098793 IDA
    presynapse GO:0098793 IEP
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IEP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Kif2c in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Kif2c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A2 6522
Affinity Capture-MS Homo sapiens
2 TUBA1A 7846
Affinity Capture-MS Homo sapiens
3 RNF170 81790
Affinity Capture-MS Homo sapiens
4 DEPDC1  
Affinity Capture-MS Homo sapiens
5 NPIPB3  
Affinity Capture-MS Homo sapiens
6 Tnik  
Affinity Capture-MS Mus musculus
7 Nphp4  
Affinity Capture-MS Mus musculus
8 ERGIC1 57222
Affinity Capture-MS Homo sapiens
9 Eed  
Affinity Capture-MS Mus musculus
10 Tmem173  
Proximity Label-MS Mus musculus
11 EXT1 2131
Affinity Capture-MS Homo sapiens
12 DGCR14  
Two-hybrid Homo sapiens
13 LOC613037  
Affinity Capture-MS Homo sapiens
14 YME1L1 10730
Affinity Capture-MS Homo sapiens
15 TBC1D7  
Affinity Capture-MS Homo sapiens
16 MRPS12  
Affinity Capture-MS Homo sapiens
17 TRAPPC13 80006
Affinity Capture-MS Homo sapiens
18 ZNF273  
Affinity Capture-MS Homo sapiens
19 CENPC  
Affinity Capture-MS Homo sapiens
20 THOC3  
Two-hybrid Homo sapiens
21 NUSAP1 51203
Two-hybrid Homo sapiens
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