Gene description for HSD17B12
Gene name hydroxysteroid (17-beta) dehydrogenase 12
Gene symbol HSD17B12
Other names/aliases KAR
SDR12C1
Species Homo sapiens
 Database cross references - HSD17B12
ExoCarta ExoCarta_51144
Entrez Gene 51144
HGNC 18646
MIM 609574
UniProt Q53GQ0  
 HSD17B12 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for HSD17B12
Molecular Function
    collagen binding GO:0005518 IEA
    heparin binding GO:0008201 IEA
    estradiol 17-beta-dehydrogenase activity GO:0004303 IEA
    fibronectin binding GO:0001968 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of cell-substrate adhesion GO:0010811 IEA
    small molecule metabolic process GO:0044281 TAS
    oxidation-reduction process GO:0055114 IEA
    cellular lipid metabolic process GO:0044255 TAS
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    triglyceride biosynthetic process GO:0019432 TAS
    estrogen biosynthetic process GO:0006703 IEA
    fatty acid biosynthetic process GO:0006633 IEA
    extracellular matrix organization GO:0030198 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    integral component of membrane GO:0016021 IEA
    extracellular matrix GO:0031012 IEA
 Experiment description of studies that identified HSD17B12 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSD17B12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HSD17B12 is involved
PathwayEvidenceSource
Androgen biosynthesis TAS Reactome
Synthesis of very long-chain fatty acyl-CoAs TAS Reactome





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