Gene description for ELOVL1
Gene name ELOVL fatty acid elongase 1
Gene symbol ELOVL1
Other names/aliases CGI-88
Ssc1
Species Homo sapiens
 Database cross references - ELOVL1
ExoCarta ExoCarta_64834
Entrez Gene 64834
HGNC 14418
MIM 611813
UniProt Q9BW60  
 ELOVL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ELOVL1
Molecular Function
    protein binding GO:0005515 IPI
    fatty acid elongase activity GO:0009922 IDA
Biological Process
    fatty acid elongation, saturated fatty acid GO:0019367 IDA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    small molecule metabolic process GO:0044281 TAS
    alpha-linolenic acid metabolic process GO:0036109 TAS
    unsaturated fatty acid metabolic process GO:0033559 TAS
    very long-chain fatty acid biosynthetic process GO:0042761 IDA
    sphingolipid biosynthetic process GO:0030148 IMP
    triglyceride biosynthetic process GO:0019432 TAS
    cellular lipid metabolic process GO:0044255 TAS
    linoleic acid metabolic process GO:0043651 TAS
    fatty acid elongation, monounsaturated fatty acid GO:0034625 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    integral component of endoplasmic reticulum membrane GO:0030176 NAS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified ELOVL1 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ELOVL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMD10 5716
Affinity Capture-MS Homo sapiens
2 TWF2 11344
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here