Gene description for SNX4
Gene name sorting nexin 4
Gene symbol SNX4
Other names/aliases ATG24B
Species Homo sapiens
 Database cross references - SNX4
ExoCarta ExoCarta_8723
Entrez Gene 8723
HGNC 11175
MIM 605931
UniProt O95219  
 SNX4 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for SNX4
Molecular Function
    protein binding GO:0005515 IPI
    epidermal growth factor receptor binding GO:0005154 IDA
    leptin receptor binding GO:1990460 IDA
    transferrin receptor binding GO:1990459 IDA
    phosphatidylinositol binding GO:0035091 IMP
    insulin receptor binding GO:0005158 IDA
Biological Process
    endocytic recycling GO:0032456 IMP
    protein transport GO:0015031 IMP
    endocytosis GO:0006897 IBA
    positive regulation of histamine secretion by mast cell GO:1903595 IMP
    vesicle organization GO:0016050 IBA
Subcellular Localization
    early endosome membrane GO:0031901 IDA
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IDA
    SNARE complex GO:0031201 IDA
    protein complex GO:0043234 IDA
    cytoplasmic dynein complex GO:0005868 IDA
    extrinsic component of membrane GO:0019898 IBA
    plasma membrane GO:0005886 IDA
    endosome GO:0005768 IBA
 Experiment description of studies that identified SNX4 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNX4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNX2 6643
Invivo Homo sapiens
Invitro Homo sapiens
2 LEPR 3953
Invivo Homo sapiens
3 PDGFRA  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
4 INSR 3643
Invivo Homo sapiens
5 EGFR 1956
Invivo Homo sapiens
6 BIN1 274
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 PDGFRB 5159
Invitro Homo sapiens
8 SNX6 58533
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SNX4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here